N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Chemical Properties

Melting point:

110-112°C

Boiling point:

411.2±45.0 °C(Predicted)

Density 

1.101±0.06 g/cm3(Predicted)

vapor pressure 

0-0Pa at 20-25℃

storage temp. 

-20°C Freezer

solubility 

DMSO, Methanol

pka

14.62±0.70(Predicted)

form 

Crystalline Powder

color 

Light gray

InChIKey

NJKRFQIWDJSYOK-UHFFFAOYSA-N

LogP

0.74 at 20℃ and pH12

CAS DataBase Reference

5294-61-1(CAS DataBase Reference)

Safety Information

HazardClass 

IRRITANT

HS Code 

2934990002

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Usage And Synthesis

Chemical Properties

Pale Beige Solid

Uses

A metabolite of Ranolazine.

Synthesis

The general procedure for the synthesis of N-(2,6-dimethylphenyl)-1-piperazine acetamide from piperazine hexahydrate and 2,6-dimethylchloroacetanilide was as follows: 58.3 g (0.3 mol) of piperazine hexahydrate was dissolved in 230 ml of ethanol, followed by the addition of 50.0 g (0.25 mol) of 2-chloro-N-(2,6-dimethylphenyl)acetamide. The reaction mixture was heated under reflux conditions for 3 hours until the reaction was complete. After completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure followed by addition of 80 ml of water. The mixture was extracted with water and dichloromethane, and after separation of the organic layer, it was concentrated under vacuum at 60 °C to give 39.4 g of N-(2,6-dimethylphenyl)-1-piperazine acetamide in 63% yield. The product was characterized by 1HNMR (CDCl3): δ 2.23-2.27 (s, 6H), 2.67 (s, 4H), 2.96-2.98 (t, 4H), 3.19-3.21 (s, 2H), 7.08-7.26 (m, 3H), 8.69 (s, 1H).

References

[1] Patent: US2013/90475, 2013, A1. Location in patent: Paragraph 0029; 0030

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine(5294-61-1)Related Product Information

• Thioacetamide
• Bensulfuron methyl
• CARBONYL SULFIDE
• PYRAZOPHOS
• Acetamide
• Acetaminophen
• Piperazine
• Kresoxim-methyl
• Methyl acrylate
• Chlorodimethylphenylsilane
• Methylparaben
• 2',6'-Pipecoloxylidide
• N-(2,6-Dimethylphenyl)-2-picolinamide
• N-(2,4,6-Trichlorophenyl)maleimide
• N,N-Dimethylacetamide
• Methyl
• Parathion-methyl
• Methyl bromide