5-METHOXYFLAVONE
5-METHOXYFLAVONE Basic information
- Product Name:
- 5-METHOXYFLAVONE
- Synonyms:
-
- METHOXYFLAVONE, 5-
- 5-METHOXYFLAVONE
- 5-methoxy-2-phenyl-4-benzopyrone
- 5-Methoxyflavone,97%
- 5-Methoxy-2-phenyl-4H-1-benzopyran-4-one
- 5-methoxy-2-phenyl-chromen-4-one
- 5-methoxy-2-phenylchromen-4-one
- 5-methoxy-2-phenyl-chromone
- CAS:
- 42079-78-7
- MF:
- C16H12O3
- MW:
- 252.26
- EINECS:
- 255-652-0
- Product Categories:
-
- Mono-substituted Flavones
- Mol File:
- 42079-78-7.mol
5-METHOXYFLAVONE Chemical Properties
- Melting point:
- 131-133°C
- Boiling point:
- 422.5±45.0 °C(Predicted)
- Density
- 1,155g/cm
- refractive index
- 1,548
- storage temp.
- Store at -20°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Almost white
- LogP
- 3.470 (est)
- CAS DataBase Reference
- 42079-78-7(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-36
- WGK Germany
- 3
- HS Code
- 2932.99.7000
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
5-METHOXYFLAVONE Usage And Synthesis
Uses
5-Methoxyflavone is a flavenoid and dietary derived inhibitor of cell proliferation.
Definition
ChEBI: 5-Methoxyflavone is an ether and a member of flavonoids.
Biological Activity
5-Methoxyflavone, a flavonoid, is an inhibitor of DNA polymerase-beta and a neuroprotectant against beta-amyloid toxicity. Possesses central nervous system sedative effect by regulating ionophilic GABAA receptors.
in vitro
5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. It (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF , 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 ( DR5) in a time-dependent manner.
in vivo
5-Methoxyflavone (100, 150 mg/kg, ip) significantly decreases the latency time to loss of righting reflex. It (50, 100 and 150 mg/kg, ip) exhibits a significant and dose decreases -dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, ip) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, ip) completely abolishesed the grooming response similar to diazepam treated animals.
target
| Target | Value |
| DNA polymerase β () |
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5-METHOXYFLAVONE(42079-78-7)Related Product Information
- 5,6,7-TRIMETHOXYFLAVONE
- SCUTELLAREIN TETRAMETHYL ETHER
- 3',4',5',5,7-PENTAMETHOXYFLAVONE
- 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE
- 5-O-Methyl Quercetin;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-5-Methoxy-4H-1-benzopyran-4-one
- 5-METHOXYFLAVONE
- 5,7-DIMETHOXYFLAVONE
- 3,5-DIMETHOXYFLAVONE
- EUPATORIN-5-METHYL ETHER
- 3-HYDROXY-5-METHOXYFLAVONE
- 3',4',5',5,6,7-HEXAMETHOXYFLAVONE
- Diosmetin
- 4',5,7-TRIHYDROXY-3'-METHOXYFLAVONE
- 3-HYDROXY-7-METHOXYFLAVONE
- 4',5-DIHYDROXY-7-METHOXYFLAVONE,5,4'-DIHYDROXY-7-METHOXYFLAVONE
- 5,6-DIHYDROXY-7-METHOXYFLAVONE
- 3-HYDROXY-6-METHOXYFLAVONE
- Tangeretin