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BENZYL ISOTHIOCYANATE

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BENZYL ISOTHIOCYANATE Basic information

Product Name:
BENZYL ISOTHIOCYANATE
Synonyms:
  • TIMTEC-BB SBB002731
  • Benzyl isothiocyanate, 97+%
  • benzyl isorhodanate
  • benzyl isorhodanide
  • benzyl isothiocyanide
  • Benzyl mustard oil, Isothiocyanotaomethylbenzene
  • BITC
  • Benzyl isothiocyanate,98%
CAS:
622-78-6
MF:
C8H7NS
MW:
149.21
EINECS:
210-753-9
Product Categories:
  • Inhibitors
  • Allium cepa (Onion)
  • Armoracia rusticana (Horseradish)
  • Building Blocks
  • Chemical Synthesis
  • Nutrition Research
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Organic Building Blocks
  • Phytochemicals by Plant (Food/Spice/Herb)
  • Sulfur Compounds
  • Thiocyanates/Isothiocyanates
Mol File:
622-78-6.mol
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BENZYL ISOTHIOCYANATE Chemical Properties

Melting point:
41 °C
Boiling point:
242-243 °C(lit.)
Density 
1.125 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.6018(lit.)
FEMA 
4428 | BENZYL ISOTHIOCYANATE
Flash point:
>235 °F
storage temp. 
2-8°C
solubility 
0.1g/l
form 
Liquid
Specific Gravity
1.125
color 
Clear yellow
Odor
at 0.10 % in dipropylene glycol. mild watercress dusty medicinal horseradish oily
Odor Type
watercress
Water Solubility 
Hydrolyzes in water.
Sensitive 
Moisture Sensitive
JECFA Number
1562
BRN 
386135
InChIKey
MDKCFLQDBWCQCV-UHFFFAOYSA-N
LogP
3.16
CAS DataBase Reference
622-78-6(CAS DataBase Reference)
EPA Substance Registry System
Benzene, (isothiocyanatomethyl)- (622-78-6)
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Safety Information

Hazard Codes 
Xn,C,T
Risk Statements 
20/21/22-36/37/38-42/43
Safety Statements 
26-36/37/39
RIDADR 
2810
WGK Germany 
3
RTECS 
NX8250000
8-19-21
Hazard Note 
Corrosive/Harmful/Store under nitrogen
TSCA 
T
HazardClass 
8
PackingGroup 
III
HS Code 
29309090
Toxicity
mmo-sat 150 mg/plate ABCHA6 44,3017,80

MSDS

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BENZYL ISOTHIOCYANATE Usage And Synthesis

Chemical Properties

clear yellow liquid

Chemical Properties

Pale yellowish liquid; strong, penetrating aroma.

Occurrence

Reported found in common cress, Lepidium sativum, nasturtium, and Tropaeolum majus.

Uses

antineoplastic, antibacterial, antifungal

Uses

Benzyl isothiocyanate has been used in the preparation of S-(N-benzylthiocarbamoyl)-L-glutathione and S-(N-benzylthiocarbamoyl)-L-cysteine.

Uses

A novel medical application of isothiocyanate ester in treating various leukemia, with low toxicity, which includes benzyl isothiocyanate, phenylethyl isothiocyanate, allyl isothiocyanate, sulforaphane, and erucin. Benzyl isothiocyanate (BITC) inhibits the growth of human pancreatic cancer cells by inducing apoptosis.

Definition

ChEBI: Benzyl isothiocyanate is an isothiocyanate and a member of benzenes. It has a role as an antibacterial drug.

Preparation

Benzyl isothiocyanate is synthesized by the following two methods: I) from Benzylamine via Thiuramdisulfide via Sodiumsalt with Iodine to Benzyl-isothiocyanate. 2) from Benzylamine and Thiocarbonyl chloride.

Aroma threshold values

Medium strength odor, watercress type; recommend smelling in a 1.0% solution or less.

Synthesis Reference(s)

Tetrahedron Letters, 33, p. 7021, 1992 DOI: 10.1016/S0040-4039(00)60922-X

General Description

Benzyl isothiocyanate is a naturally-occurring constituent of cruciferous vegetables. It has antibacterial properties and its metabolism in man has been investigated. It inhibits chemically induced cancer in animal models.

Hazard

Very irritant to tissues.

Biochem/physiol Actions

Odor at 1.0%: Vegetative cabbage and radishlike, green with a musty sulfurous earthiness reminiscent of mustard greens.Taste at 0.5ppm: Green vegetative cabbage, kimchi, radish and wasabi-like with green leafy nuances and imparting a strong trigeminal tongue numbing and raspy sensation.

Safety Profile

Poison by intraperitoneal andsubcutaneous routes. Intensely irritating. Mutation datareported. Moderate fire hazard via heat, flame, andoxidizers. To fight fire, use water, spray, foam, drychemical. When heated to decomposition it emits verytoxic NOx

Solubility in organics

Soluble in alcohol and oils.

BENZYL ISOTHIOCYANATE Preparation Products And Raw materials

Preparation Products

BENZYL ISOTHIOCYANATESupplier

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