BENZYL ISOTHIOCYANATE
BENZYL ISOTHIOCYANATE Basic information
- Product Name:
- BENZYL ISOTHIOCYANATE
- Synonyms:
-
- TIMTEC-BB SBB002731
- Benzyl isothiocyanate, 97+%
- benzyl isorhodanate
- benzyl isorhodanide
- benzyl isothiocyanide
- Benzyl mustard oil, Isothiocyanotaomethylbenzene
- BITC
- Benzyl isothiocyanate,98%
- CAS:
- 622-78-6
- MF:
- C8H7NS
- MW:
- 149.21
- EINECS:
- 210-753-9
- Product Categories:
-
- Inhibitors
- Allium cepa (Onion)
- Armoracia rusticana (Horseradish)
- Building Blocks
- Chemical Synthesis
- Nutrition Research
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Organic Building Blocks
- Phytochemicals by Plant (Food/Spice/Herb)
- Sulfur Compounds
- Thiocyanates/Isothiocyanates
- Mol File:
- 622-78-6.mol
BENZYL ISOTHIOCYANATE Chemical Properties
- Melting point:
- 41 °C
- Boiling point:
- 242-243 °C(lit.)
- Density
- 1.125 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.6018(lit.)
- FEMA
- 4428 | BENZYL ISOTHIOCYANATE
- Flash point:
- >235 °F
- storage temp.
- 2-8°C
- solubility
- 0.1g/l
- form
- Liquid
- Specific Gravity
- 1.125
- color
- Clear yellow
- Odor
- at 0.10 % in dipropylene glycol. mild watercress dusty medicinal horseradish oily
- Odor Type
- watercress
- Water Solubility
- Hydrolyzes in water.
- Sensitive
- Moisture Sensitive
- JECFA Number
- 1562
- BRN
- 386135
- InChIKey
- MDKCFLQDBWCQCV-UHFFFAOYSA-N
- LogP
- 3.16
- CAS DataBase Reference
- 622-78-6(CAS DataBase Reference)
- EPA Substance Registry System
- Benzene, (isothiocyanatomethyl)- (622-78-6)
Safety Information
- Hazard Codes
- Xn,C,T
- Risk Statements
- 20/21/22-36/37/38-42/43
- Safety Statements
- 26-36/37/39
- RIDADR
- 2810
- WGK Germany
- 3
- RTECS
- NX8250000
- F
- 8-19-21
- Hazard Note
- Corrosive/Harmful/Store under nitrogen
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29309090
- Toxicity
- mmo-sat 150 mg/plate ABCHA6 44,3017,80
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
BENZYL ISOTHIOCYANATE Usage And Synthesis
Chemical Properties
clear yellow liquid
Chemical Properties
Pale yellowish liquid; strong, penetrating aroma.
Occurrence
Reported found in common cress, Lepidium sativum, nasturtium, and Tropaeolum majus.
Uses
antineoplastic, antibacterial, antifungal
Uses
Benzyl isothiocyanate has been used in the preparation of S-(N-benzylthiocarbamoyl)-L-glutathione and S-(N-benzylthiocarbamoyl)-L-cysteine.
Uses
A novel medical application of isothiocyanate ester in treating various leukemia, with low toxicity, which includes benzyl isothiocyanate, phenylethyl isothiocyanate, allyl isothiocyanate, sulforaphane, and erucin. Benzyl isothiocyanate (BITC) inhibits the growth of human pancreatic cancer cells by inducing apoptosis.
Definition
ChEBI: Benzyl isothiocyanate is an isothiocyanate and a member of benzenes. It has a role as an antibacterial drug.
Preparation
Benzyl isothiocyanate is synthesized by the following two methods: I) from Benzylamine via Thiuramdisulfide via Sodiumsalt with Iodine to Benzyl-isothiocyanate. 2) from Benzylamine and Thiocarbonyl chloride.
Aroma threshold values
Medium strength odor, watercress type; recommend smelling in a 1.0% solution or less.
Synthesis Reference(s)
Tetrahedron Letters, 33, p. 7021, 1992 DOI: 10.1016/S0040-4039(00)60922-X
General Description
Benzyl isothiocyanate is a naturally-occurring constituent of cruciferous vegetables. It has antibacterial properties and its metabolism in man has been investigated. It inhibits chemically induced cancer in animal models.
Hazard
Very irritant to tissues.
Biochem/physiol Actions
Odor at 1.0%: Vegetative cabbage and radishlike, green with a musty sulfurous earthiness reminiscent of mustard greens.Taste at 0.5ppm: Green vegetative cabbage, kimchi, radish and wasabi-like with green leafy nuances and imparting a strong trigeminal tongue numbing and raspy sensation.
Safety Profile
Poison by intraperitoneal andsubcutaneous routes. Intensely irritating. Mutation datareported. Moderate fire hazard via heat, flame, andoxidizers. To fight fire, use water, spray, foam, drychemical. When heated to decomposition it emits verytoxic NOx
Solubility in organics
Soluble in alcohol and oils.
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BENZYL ISOTHIOCYANATE(622-78-6)Related Product Information
- Phenethyl isothiocyanate
- Fluorescein isothiocyanate isomer I
- Guanidine thiocyanate
- PROPYL ISOTHIOCYANATE
- 4-BROMOPHENYL ISOTHIOCYANATE
- ISOBUTYL ISOTHIOCYANATE
- Phenyl isothiocyanate
- Methyl isothiocyanate
- Butyl isothiocyanate
- Ethoxycarbonyl Isothiocyanate
- 3-S-Isothiuronium propyl sulfonate
- ACETYL ISOTHIOCYANATE
- Fluorescein isothiocyanate
- 1-ADAMANTYL ISOTHIOCYANATE
- CYCLOHEXYL ISOTHIOCYANATE
- ISOTHIOCYANIC ACID 3-BUTEN-1-YL ESTER
- 3,4-DIMETHOXYPHENYL ISOTHIOCYANATE
- Ethyl isothiocyanate