Narnatumab
Narnatumab Basic information
- Product Name:
- Narnatumab
- Synonyms:
-
- Narnatumab
- Research Grade Narnatumab(DHG03401)
- Narnatumab (anti-RON)
- Research Grade Narnatumab
- CAS:
- 1188275-92-4
- MW:
- 0
- Mol File:
- Mol File
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Narnatumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Narnatumab Usage And Synthesis
Uses
Narnatumab (IMC-RON8) is a neutralizing human monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP), with a Kd of 32 pM. Narnatumab can be used for the research of cancer[1].
in vivo
Narnatumab (2-60 mg/kg; i.p. every 3 days) shows antitumor activity in non-small cell lung cancer (NSCLC) and bladder cancer models in athymic mice[1].
Narnatumab exhibits terminal half-life (t1/2=5.2 d) and achieves antitumor effects at a steady-state plasma trough level of approximately 140 μg/mL in mice[1].
| Animal Model: | Female athymic nu/nu mice (6-8 weeks) were injected NCI-H292 and BFTC-905 cells[1] |
| Dosage: | 2, 20, 60 mg/kg |
| Administration: | I.p. every 3 days for 36 and 18 days |
| Result: | Inhibited tumor growth in a dose-dependent manner. |
References
[1] LoRusso PM, et, al. Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors. Invest New Drugs. 2017 Aug;35(4):442-450. DOI:10.1007/s10637-016-0413-0
NarnatumabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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ShangHai Biochempartner Co.,Ltd
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Guangzhou Hongyuan Chemical Co.,Ltd
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Wuhan Chemstan Biotechnology Co., Ltd.
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- 027-65317797 15926423062
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