alpha-yohimbine
alpha-yohimbine Basic information
- Product Name:
- alpha-yohimbine
- Synonyms:
-
- methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate
- 4-(2-amino-1-hydroxyethyl)-2-methoxyphenol hydrochloride(1:1)
- Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, (16b,17a,20a)-
- Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16β,17α,20α)-
- α-Yohimbine
- Methyl (16?,17?,20?)-17-hydroxyyohimban-16-carboxylate
- methyl17α-hydroxy-20α-yohimban-16β-carboxylate(α-yohimbine)
- CAS:
- 131-03-3
- MF:
- C21H26N2O3
- MW:
- 354.44
- EINECS:
- 205-006-9
- Mol File:
- 131-03-3.mol
alpha-yohimbine Chemical Properties
- Melting point:
- 243-244°
- alpha
- D19 -18° (pyridine); D19 -27° (abs alcohol)
- Boiling point:
- 543.0±50.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- pka
- 6.34(at 25℃)
- form
- Solid
- color
- Light yellow to brown
alpha-yohimbine Usage And Synthesis
Uses
Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis[1].
Definition
ChEBI: Rauwolscine is a methyl 17-hydroxy-20xi-yohimban-16-carboxylate.
in vivo
Rauwolscine (0.5 mg/kg, daily) reduces tumor growth by enhancing apoptosis and reducing cell proliferation in Balb/c female virgin mice[1].
Rauwolscine (i.v., 2.24 mg/kg) can significantly release lick-shock conflict responding in rats similar to the α agonist clonidine (0.022 mg/kg) and the benzodiazepine diazepam (0.5 mg/kg) [2].
References
[1] A Bruzzone, et al. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008 Oct;155(4):494-504. DOI:10.1038/bjp.2008.278
[2] S La Marca, et al. The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration. Life Sci. 1994;54(10):PL179-84. DOI:10.1016/0024-3205(94)00556-7
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- RAUWOLSCINE, [METHYL-3H]-