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Aceglatone

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Aceglatone Basic information

Product Name:
Aceglatone
Synonyms:
  • Aceglatone
  • (2-acetyloxy-3,7-dioxo-4,8-dioxabicyclo[3.3.0]oct-6-yl) acetate
  • 2-O,5-O-Diacetyl-D-glucaric acid 1,4:6,3-dilactone
  • 2,5-Di-O-acetyl-D-glucaro-(1→4:6→3)-dilactone
  • 2,5-di-O-Acetyl-D-glucosaccharo-(1→4:6→3)-dilactone
  • D-Glucaric acid, di-γ-lactone, 2,5-diacetate
  • Furo[3,2-b]furan, D-glucaric acid deriv.
  • Glucaric acid, 1,4:6,3-dilactone, diacetate (7CI)
CAS:
642-83-1
MF:
C10H10O8
MW:
258.18
Mol File:
642-83-1.mol
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Aceglatone Chemical Properties

Melting point:
185-186° (Hirasaka)
Density 
1.49
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Aceglatone Usage And Synthesis

Uses

Aceglatone, an antineoplastic agent, is a β-glucuronidase inhibitor. Aceglatone is a compound that inhibits colon carcinogenesis and prevents the induction of colon cancer by inhibiting the hydrolysis of glucuronides. Aceglatone reduces cell proliferation, induces apoptosis and inhibits DNA synthesis in human colon cancer cells[1].

Definition

ChEBI: Aceglatone is an organic molecular entity.

References

[1] Effects of synthetic and natural in vivo inhibitors of β-glucuronidase on azoxymethane-induced colon carcinogenesis in rats DOI:10.3892/mmr_00000022

AceglatoneSupplier

LGM Pharma
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TargetMol Chemicals Inc.
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Dideu Industries Group Limited
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+86-29-89586680 +86-15129568250
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Hubei xin bonus chemical co. LTD
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86-13657291602
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Hangzhou Jinghao Biotechnology Co., LTD
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17513242016 17513242016
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1576861551@qq.com
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