DL-4-Chlorophenylglycine Chemical Properties

Melting point:

220-230°C

Boiling point:

328.8±32.0 °C(Predicted)

Density 

1.392±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Soluble in 0.1mol/L NaOH (almost transparency).

pka

1.81±0.10(Predicted)

form 

Solid

color 

Off-white

Major Application

peptide synthesis

InChI

InChI=1S/C8H8ClNO2/c9-6-3-1-5(2-4-6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12)

InChIKey

QGJGBYXRJVIYGA-UHFFFAOYSA-N

SMILES

C(C1C=CC(Cl)=CC=1)(N)C(=O)O

CAS DataBase Reference

6212-33-5(CAS DataBase Reference)

EPA Substance Registry System

Benzeneacetic acid, .alpha.-amino-4-chloro- (6212-33-5)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

TSCA 

TSCA listed

HS Code 

2922.49.8000

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich

DL-4-Chlorophenylglycine Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Ammonia and sodium hydroxide solution were placed in a container and cooled to 0??C in an ice bath; under the condition of 0??C in the container ice bath, sodium hydroxide solution was added to ammonia, and ammonia gas was passed through to produce a phase I solution; subsequently, the catalyst and p-chlorobenzaldehyde were added to chloroform, and the phase II solution was produced by oscillation; under the condition of the ice bath, phase I solution was added continuously to the phase II solution, and sodium saccharin was added at the same time; the container was transferred to the condition of the water bath , ammonium bicarbonate was added and allowed to stand after completion; the reaction was concentrated and p-chlorophenylglycine was precipitated.

DL-4-Chlorophenylglycine(6212-33-5)Related Product Information

• 4-Hydroxy-D-(-)-2-phenylglycine
• L-Phenylglycine
• D-2-Phenylglycine
• DL-P-Hydroxyphenylglycine
• 4-Aminophenylacetic acid
• 6-Aminocaproic acid
• Malic acid
• Glycine
• AMINO-(3,4-DICHLORO-PHENYL)-ACETIC ACID
• DL-2-(2-Chlorophenyl)glycine
• (R)-4-CHLORO PHENYLGLYCINE
• N-BOC-2-(4''-CHLOROPHENYL)-DL-GLYCINE
• DL-2-CHLOROPHENYLGLYCINE
• 4-Chlorophenylacetic acid
• Ammonia
• (4-CHLORO-PHENYL)-[(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)]-ACETIC ACID
• (3,4-DICHLORO-PHENYL)-[(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)]-ACETIC ACID
• 1-(4-CHLOROPHENYL)-2-METHOXY-2-OXO-1-ETHANAMINIUM CHLORIDE