quinaldopeptin Chemical Properties

Density 

1.45±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: soluble; DMSO: soluble; Ethanol: slightly soluble; Methanol: slightly soluble

form 

Yellow powder.

pka

6.91±0.40(Predicted)

quinaldopeptin Usage And Synthesis

Description

Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1, and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC₅₀s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (K_d = 32 nM).

Uses

Quinaldopeptin is a symmetrical, cyclic decapeptide from an Amycolatopsis sp. that is a bis-intercalator of DNA, exhibiting strong in vitro antimicrobial and cytotoxic activity. Quinaldopeptin significantly prolongs the survival time of mice inoculated with a murine tumour, and also shows weak nematocidal activity. Quinaldopeptin is related to the luzopeptins and sandramycin.

Uses

Quinaldopeptin is a bis-intercalating cyclic peptide antibiotic.

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