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Loxoprofen sodium

Basic information Safety Supplier Related

Loxoprofen sodium Basic information

Product Name:
Loxoprofen sodium
Synonyms:
  • alpha-methyl-4-((2-oxocyclopentyl)methyl)benzeneacetatesodiumsaltdihydrate
  • benzeneaceticacid,alpha-methyl-4-((2-oxocyclopentyl)methyl)-,sodiumsalt,di
  • cs-600
  • loxoprofensodium(patented-nosupply)
  • Loxoprofen sodium dihydrate, >=99%
  • Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate
  • sodium 2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoate dihydrate
  • 2-{4-[(2-Oxocyclopentyl)methyl]phenyl}propanoic acid sodium salt
CAS:
80382-23-6
MF:
C15H19NaO3
MW:
270.3
EINECS:
1806241-263-5
Product Categories:
  • Analgesics
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Antipyretic analgesics
  • APIS
  • Other APIs
  • 80382-23-6
Mol File:
80382-23-6.mol
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Loxoprofen sodium Chemical Properties

storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO: soluble
form 
A solid
color 
White to off-white
InChI
InChI=1S/C15H18O3.Na.H/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16;;/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);;
InChIKey
ALZXNWUYLUBHJL-UHFFFAOYSA-N
SMILES
C(C1CCCC1=O)C1C=CC(C(C)C(=O)O)=CC=1.[NaH]
CAS DataBase Reference
80382-23-6(CAS DataBase Reference)
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Loxoprofen sodium Usage And Synthesis

Description

Loxoprofen sodium i s an antiinflammatory/analgesic agent useful in the management of rheumatoid arthritis and related disorders. It is converted in vivo to the corresponding trans-hydroxycyclopentane analog, through which it appears to exert its activity.

Originator

Sankyo (Japan)

Uses

anti-inflammatory

Definition

ChEBI: A hydrate that is the dihydrate form of loxoprofen sodium. The parent acid, loxoprofen, is a prodrug that is rapidly converted to its active trans-alcohol metabolite following oral administration.

brand name

LOXONIN

Mechanism of action

As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.

Side effects

Adverse effects include anorexia, nausea, vomiting, bleeding, anemia, diarrhea, and constipation.

Loxoprofen sodiumSupplier

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