10-Hydroxydecanoic acid
10-Hydroxydecanoic acid Basic information
- Product Name:
- 10-Hydroxydecanoic acid
- Synonyms:
-
- 10-Hydroxycapricacid
- 10-HYDROXYDECANOIC ACID
- 10-Hydroxydecanoic acid (Synonyms: NSC 15139)
- 1-Hydroxydecanoic acid
- 10-Hydroxydecanoic acid (NSC 15139)
- Decanoic acid, 10-hydroxy-
- 10-HYDROXY-DECYLIC ACID
- 10-HYDROXYDECANOIC ACID 95%
- CAS:
- 1679-53-4
- MF:
- C10H20O3
- MW:
- 188.26
- EINECS:
- 216-848-1
- Product Categories:
-
- Biochemicals and Reagents
- Building Blocks
- C10
- Carbonyl Compounds
- Carboxylic Acids
- Chemical Synthesis
- Fatty Acids and conjugates
- Fatty Acyls
- Hydroxy Fatty Acids
- Lipids
- Organic Building Blocks
- C10Fatty Acids
- Carbonyl Compounds
- Carboxylic Acids
- Hydroxy fatty acids
- Saturated fatty acids and derivatives
- Mol File:
- 1679-53-4.mol
10-Hydroxydecanoic acid Chemical Properties
- Melting point:
- 75-77 °C (lit.)
- Boiling point:
- 330.8±15.0 °C(Predicted)
- Density
- 1.013±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 4.78±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C10H20O3/c11-9-7-5-3-1-2-4-6-8-10(12)13/h11H,1-9H2,(H,12,13)
- InChIKey
- YJCJVMMDTBEITC-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCCCCCCCCO
- LogP
- 1.847 (est)
- CAS DataBase Reference
- 1679-53-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 10-Hydroxydecanoic acid(1679-53-4)
Safety Information
- Hazard Codes
- Xi
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2918199890
MSDS
- Language:English Provider:SigmaAldrich
10-Hydroxydecanoic acid Usage And Synthesis
Chemical Properties
Crystals. Melting point 75.5-76.5℃.
Uses
Reactant involved in: • ;Synthesis of copolymers of acrylamide and sodium acryloyloxydecanoate1• ;Macrolactonization for preparation of Sansalvamide A2• ;Studies of chain length selectivity for cutinase catalyzed polycondensation reactions3• ;Ruthenium-catalyzed esterification followed by macrocyclization4• ;Synthesis of anhydrides and esters5
Uses
10-Hydroxydecanoic acid is suitable for use in a study on Novozym 435-catalyzed condensation polymerization of cis-9,10-epoxy-18-hydroxyoctadecanoic acid and its comparison with corresponding polymerization of 10-hydroxydecanoic acid.
Definition
ChEBI: A 10-carbon, omega-hydroxy fatty acid, shown to be the preferred hydroxylation product (together with the 9-OH isomer) of capric acid in biosystems, and used as a standard in lipid assays; reported to have cytotoxic effects.
General Description
10-Hydroxydecanoic acid (10-HDA) is a saturated fatty acid of hydroxy-trans-2-decenoic acid (10H2DA). Its molecule has two functional groups (-OH and -COOH). It has been reported to prevent the lipopolysaccharide-induced NO production in murine macrophages. 10-HDA has been extracted from royal jelly obtained from honeybees (Apis mellifera) and exhibits estrogenic action. Its polymerization with the polyethylene glycol-modified lipase in a transparent benzene solution has been reported to proceed by the formation of ester linkage.
in vivo
10-Hydroxydecanoic acid (1 mol/L; Intranasal injection 100 μL; once daily for 3 days) increases the number of microfold cells (M cells) in the epithelium lining the luminal surface of the nasopharyngeal-associated lymphoid tissue (NALT) in cynomolgus monkeys[2]. 10-Hydroxydecanoic acid (2.4 mg; p.o.; enteric-coated capsules taken orally once a day for 20 days) increases the number of M cells and improves the level of antigen-specific immunoglobulin A (IgA) in the follicle-associated epithelium (FAE) covering Peyer’s patches (PPs) in cynomolgus monkeys[2].
| Animal Model: | cynomolgus macaque [2] |
| Dosage: | 1 mol/L, Administer 100 μL |
| Administration: | Intranasal administration; once a day for 3 days |
| Result: | Increased number of gp2-positive cells in the epithelium overlying NALT follicles. |
| Animal Model: | cynomolgus macaque [2] |
| Dosage: | 2.4 mg |
| Administration: | p.o.; enteric-coated capsules once a day for 20 days |
| Result: | Increased the number of gp2-positive M cells. 10-HDAA (2.4 mg) enteric-coated capsules containing poliovirus antigen (106 TCID50) induced poliovirus- and influenza virus-specific IgAs on day 12 after oral administration. |
10-Hydroxydecanoic acid Preparation Products And Raw materials
Preparation Products
Raw materials
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