10-Hydroxydecanoic acid
- Product Name
- 10-Hydroxydecanoic acid
- CAS No.
- 1679-53-4
- Chemical Name
- 10-Hydroxydecanoic acid
- Synonyms
- NSC 15139;10-hydroxycapricaci;10-Hydroxycapricacid;1-Hydroxydecanoic acid;10-HYDROXYDECANOIC ACID;10-HYDROXY-DECYLIC ACID;Decanoic acid, 10-hydroxy-;10-HYDROXYDECANOIC ACID 95%;10-Hydroxydecanoic acid, 95+%;E－10－hydroxy－2－decylennic acid
- CBNumber
- CB5146543
- Molecular Formula
- C10H20O3
- Formula Weight
- 188.26
- MOL File
- 1679-53-4.mol
10-Hydroxydecanoic acid Property
- Melting point:
- 75-77 °C (lit.)
- Boiling point:
- 330.8±15.0 °C(Predicted)
- Density
- 1.013±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 4.78±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Cosmetics Ingredients Functions
- SKIN CONDITIONING
- InChI
- InChI=1S/C10H20O3/c11-9-7-5-3-1-2-4-6-8-10(12)13/h11H,1-9H2,(H,12,13)
- InChIKey
- YJCJVMMDTBEITC-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCCCCCCCCO
- LogP
- 1.847 (est)
- CAS DataBase Reference
- 1679-53-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 10-Hydroxydecanoic acid(1679-53-4)
Safety
- Hazard Codes
- Xi
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2918199890
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 379700
- Product name
- 10-Hydroxydecanoic acid
- Purity
- technical grade
- Packaging
- 500mg
- Price
- $102
- Updated
- 2023/06/20
- Product number
- 379700
- Product name
- 10-Hydroxydecanoic acid
- Purity
- technical grade
- Packaging
- 5g
- Price
- $144
- Updated
- 2023/06/20
- Product number
- H1090
- Product name
- 10-Hydroxydecanoic Acid
- Purity
- min. 97.0 %
- Packaging
- 5G
- Price
- $66
- Updated
- 2025/07/31
- Product number
- H1090
- Product name
- 10-Hydroxydecanoic Acid
- Purity
- min. 97.0 %
- Packaging
- 25G
- Price
- $197
- Updated
- 2025/07/31
- Product number
- 30458
- Product name
- 10-hydroxy Decanoic Acid
- Packaging
- 1g
- Price
- $56
- Updated
- 2024/03/01
10-Hydroxydecanoic acid Chemical Properties,Usage,Production
Chemical Properties
Crystals. Melting point 75.5-76.5℃.
Uses
Reactant involved in: • ;Synthesis of copolymers of acrylamide and sodium acryloyloxydecanoate1• ;Macrolactonization for preparation of Sansalvamide A2• ;Studies of chain length selectivity for cutinase catalyzed polycondensation reactions3• ;Ruthenium-catalyzed esterification followed by macrocyclization4• ;Synthesis of anhydrides and esters5
Uses
10-Hydroxydecanoic acid is suitable for use in a study on Novozym 435-catalyzed condensation polymerization of cis-9,10-epoxy-18-hydroxyoctadecanoic acid and its comparison with corresponding polymerization of 10-hydroxydecanoic acid.
Definition
ChEBI: A 10-carbon, omega-hydroxy fatty acid, shown to be the preferred hydroxylation product (together with the 9-OH isomer) of capric acid in biosystems, and used as a standard in lipid assays; reported to have cytotoxic effects.
General Description
10-Hydroxydecanoic acid (10-HDA) is a saturated fatty acid of hydroxy-trans-2-decenoic acid (10H2DA). Its molecule has two functional groups (-OH and -COOH). It has been reported to prevent the lipopolysaccharide-induced NO production in murine macrophages. 10-HDA has been extracted from royal jelly obtained from honeybees (Apis mellifera) and exhibits estrogenic action. Its polymerization with the polyethylene glycol-modified lipase in a transparent benzene solution has been reported to proceed by the formation of ester linkage.
Synthesis
The alkaline cleavage of ricinoleates may be carried out in ethanol at temperatures of 190-200℃ using two to three equivalents of NaOH to give yields up to 69% of pure 10-hydroxydecanoic acid. This method avoids the use of large excesses of alkali as well as the use of high boiling alcohols as reaction media.
In a typical experiment we placed 46.8 g (150 mmoles) of methyl ricinoleate and a solution of 12.0 g (300 mmoles) of NaOH in 100 ml of 95% ethanol. The autoclave was placed in an oven at 190-200℃ for 16-18 hr and then cooled to room temperature, vented to remove a certain amount of ethylene (identified by its mass spectrum) produced during heating and opened. After dissolving the semisolid contents in about 500 ml of water, the resulting solution was extracted with three 200 ml portions of ether to remove neutral material. This step may be omitted if it is not desired to retain the 2-octanol formed as coproduct. The aqueous phase was then acidified with 30 ml of concentrated hydrochloric acid, and the liberated acids extracted with two 200 ml portions of ether. After drying over magnesium sulfate and evaporation under reduced pressure to give about 35 g of solid, the crude acids were then dissolved in 100 ml of warm ethyl acetate and 100 ml of heptane was added. After standing overnight at 0℃ the mixture deposited 20.2 g of crystals, mp 71.5-74.5℃ which on recrystallization from benzene, 140 ml, yielded 19.4 g (104 mmoles, 69%) of 10-hydroxydecanoic acid, mp 73-75℃ (lit. 75-76℃).
The above conditions are optimal when methyl ricinoleate is utilized, but the cleavage will proceed at lower temperatures. At 160 C about 41% yield of product was obtained after approximately the same reaction time.[1]
in vivo
10-Hydroxydecanoic acid (1 mol/L; Intranasal injection 100 μL; once daily for 3 days) increases the number of microfold cells (M cells) in the epithelium lining the luminal surface of the nasopharyngeal-associated lymphoid tissue (NALT) in cynomolgus monkeys[2]. 10-Hydroxydecanoic acid (2.4 mg; p.o.; enteric-coated capsules taken orally once a day for 20 days) increases the number of M cells and improves the level of antigen-specific immunoglobulin A (IgA) in the follicle-associated epithelium (FAE) covering Peyer’s patches (PPs) in cynomolgus monkeys[2].
| Animal Model: | cynomolgus macaque [2] |
| Dosage: | 1 mol/L, Administer 100 μL |
| Administration: | Intranasal administration; once a day for 3 days |
| Result: | Increased number of gp2-positive cells in the epithelium overlying NALT follicles. |
| Animal Model: | cynomolgus macaque [2] |
| Dosage: | 2.4 mg |
| Administration: | p.o.; enteric-coated capsules once a day for 20 days |
| Result: | Increased the number of gp2-positive M cells. 10-HDAA (2.4 mg) enteric-coated capsules containing poliovirus antigen (106 TCID50) induced poliovirus- and influenza virus-specific IgAs on day 12 after oral administration. |
References
[1] CARL A. ELLIGER M. J D. A convenient preparation of 10-hydroxydecanoic acid[J]. Journal of the American Oil Chemists Society, 1972, 49 4: 278. DOI:10.1007/BF02582593.
10-Hydroxydecanoic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 10-Hydroxydecanoic acid manufacturers
- Product
- 10-Hydroxydecanoic acid 1679-53-4
- Price
- US $500.00-300.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-23
- Product
- 10-Hydroxydecanoic acid 1679-53-4
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05
- Product
- 10-Hydroxydecanoic acid 1679-53-4
- Price
- US $20.00-3.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-10-20