L-Homocystine Chemical Properties

Melting point:

281-284 °C (dec.)(lit.)

alpha 

77 º (c=1% in 1N HCl)

Boiling point:

507.6±50.0 °C(Predicted)

Density 

1.443±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

H2O : 5 mg/mL (18.63 mM; ultrasonic and adjust pH to 3 with H2O)DMSO : 1 mg/mL (3.73 mM; ultrasonic and adjust pH to 5 with HCl)

form 

Powder

pka

1.90±0.10(Predicted)

BRN 

1728583

InChIKey

ZTVZLYBCZNMWCF-WDSKDSINSA-N

CAS DataBase Reference

626-72-2(CAS DataBase Reference)

EPA Substance Registry System

L-Homocystine (626-72-2)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

29309090

MSDS

• Language:English Provider:SigmaAldrich

L-Homocystine Usage And Synthesis

Chemical Properties

L-homocysteine is an aliphatic amino acid with the molecular formula (C8H16N2O4S2). It is a white powder with an acidic taste and is easily soluble in water. It has limited solubility in ethanol. L-homocysteine has a sulfhydryl group on its side chain, which allows it to form disulfide bonds with other L-homocysteine residues in proteins. This feature contributes to the stable three-dimensional structure of proteins. As a result, L-homocysteine finds extensive applications in industries such as pharmaceuticals, food, feed, and cosmetics.

Uses

Increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.

Definition

ChEBI: L,L-homocystine is a homocystine in which both chiral centres have L configuration. It is functionally related to a L-homocysteine. It is a tautomer of a L,L-homocystine zwitterion.

Synthesis

L-homoserine(626-72-2) is biosynthesized from L-aspartate, which is synthesized from oxaloacetate, a TCA cycle intermediate. Homoserine is activated through esterification to form the O-acetyl ester by the enzyme homoserine O-acetyltransferase. In certain organisms, including the yeast Saccharomyces cerevisiae and certain bacteria, hydrogen sulfide reacts with O-acetyl-L-homoserine, replacing the acetyl group and forming L-homocysteine.

Purification Methods

The acid (3g) is dissolved in freshly boiled H2O (30mL) under N2, cooled under N2 (all operations should be under N2), absolute EtOH (100mL) is added, the acid is filtered off, and a second crop is obtained by diluting the filtrate to 500mL with absolute EtOH, kept overnight in a refrigerator, filtered, washed with EtOH and dried in a vacuum. The D(R,R)-form has similar properties but is –ve in M HCl and +ve in H2O. [du Vigneaud & Patterson J Biol Chem 109 101 1935, du Vigneaud & Brown Biochemical Preparations 5 93, 95 1975, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2667-2670 1961, Beilstein 4 III 1643, 4 IV 3199, Koegel et al. J Am Chem Soc 77 5708 1955.]

L-Homocystine(626-72-2)Related Product Information

• 4-Aminobutyric acid
• D-2-Aminobutyric acid
• N-Acetyl-L-cysteine
• DL-Homocysteine
• L-Cystine
• DL-2-AMINOBUTYRIC ACID
• L-Cysteine
• Selenium sulfide
• DL-3-Aminobutyric acid
• Cyproterone acetate
• Indole-3-butyric acid
• DL-2-Aminobutyric acid
• L(+)-2-Aminobutyric acid
• 3-CARBOXYPROPYL DISULFIDE
• Butyl disulfide
• Methyl propyl disulfide
• r-Amino Butryric Acid
• ETHYL PROPYL DISULFIDE