D-2-Aminobutyric acid Chemical Properties

Melting point:

>300 °C (lit.)

alpha 

-21.2 º (c=2, 6N HCl)

Boiling point:

215.2±23.0 °C(Predicted)

Density 

1.2300 (estimate)

refractive index 

1.4650 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble

form 

Crystalline Powder

pka

2.34±0.10(Predicted)

color 

White

optical activity

[α]20/D 21 to 19°, c = 4 in H2O

Water Solubility 

soluble

BRN 

1720934

Major Application

peptide synthesis

InChI

1S/C4H9NO2/c1-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1

InChIKey

QWCKQJZIFLGMSD-GSVOUGTGSA-N

SMILES

CC[C@@H](N)C(O)=O

LogP

-0.064 (est)

CAS DataBase Reference

2623-91-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

22-24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29224999

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:D-alpha-Amino-n-butyric acid
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

D-2-Aminobutyric acid Usage And Synthesis

Chemical Properties

WHITE CRYSTALLINE POWDER

Uses

(R)-2-Aminobutyric Acid is an isomer of L-Aminobutyric Acid (A602930) which is a receptor antagonist.

Definition

ChEBI: D-alpha-aminobutyric acid is an optically active form of alpha-aminobutyric acid having D-configuration. It is an alpha-aminobutyric acid and a D-alpha-amino acid. It is an enantiomer of a L-alpha-aminobutyric acid.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Currently, the methods reported in the literature for the synthesis of D-2-aminobutyric acid such as the synthesis of D-2-aminobutyric acid from D-configuration methionine by desulfurization and other steps; ammonification and hydrolysis reaction method of butyronic acid, and chemical disassembly method. First, the racemic 2-aminobutyric acid is acetylated to obtain N-acetyl-2-aminobutyric acid, and then the aminoacylase extracted from pig kidney is used to selectively hydrolyze off the (S)-configuration N-acetyl-2-aminobutyric acid to obtain the (S)-2-aminobutyric acid, and the (R)-N-acetyl-2-aminobutyric acid which is not hydrolyzed is subjected to the racemic treatment by an appropriate method to obtain racemic 2-aminobutyric acid, thus realizing the dynamic of its 2-aminobutanoic acid. Aminobutyric acid, thus realizing its dynamic kinetic splitting and achieving a final yield of 71.9%.

IC 50

Microbial Metabolite; Human Endogenous Metabolite

D-2-Aminobutyric acid(2623-91-8)Related Product Information

• 2-AMINOBUTYRIC ACID
• Glycine
• Folic acid
• ALTRENOGEST
• Indole-3-butyric acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Hydrocortisone-17-butyrate
• Butyric Acid
• α-Lipoic Acid
• r-Amino Butryric Acid
• (S) 2-AMINOBUTYRIC ACID,(S)-(+)-2-AMINOBUTYRIC ACID
• 4-Aminobutyric acid
• 1-Amino-1-cyclohexanecarboxylic acid
• DL-3-Aminobutyric acid
• D-Phenylalanine
• D(-)-allo-Threonine
• 6-Aminopenicillanic acid
• N-Methyl-D-aspartic acid