rac-Sitagliptin
rac-Sitagliptin Basic information
- Product Name:
- rac-Sitagliptin
- Synonyms:
-
- 7-[3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine
- 7-[3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
- rac-SitagliptinSee: S491000
- 3-AMino-1-[3-(trifluoroMethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone
- 7-[1-Oxo-3-amino-4-(2,4,5-trifluorophenyl)butyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine
- 3-aMino-1-(3-(trifluoroMethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
- rac-Sitagliptin
- 1-Butanone,3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-
- CAS:
- 823817-56-7
- MF:
- C16H15F6N5O
- MW:
- 407.31
- Product Categories:
-
- All Inhibitors
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Bases & Related Reagents
- Nucleotides
- Mol File:
- 823817-56-7.mol
rac-Sitagliptin Chemical Properties
- Boiling point:
- 529.9±60.0 °C(Predicted)
- Density
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO, Ethyl Acetate, Methanol
- pka
- 7.20±0.10(Predicted)
- form
- Oil
- color
- Yellow to Light Brown
rac-Sitagliptin Usage And Synthesis
Chemical Properties
Light Brown Syrup
Uses
A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.
in vivo
In vivo, the ED50 value of sitagliptin phosphate for inhibition of plasma DPP-4 activity is calculated to be 2.3 mg/kg 7 hour postdose and 30 mg/kg 24 hour postdose in freely fed Han-Wistar rats[1].?The streptozotocin-induced type 1 diabetes mouse model exhibits elevated DPP-4 levels in the plasma that can be substantially inhibited in mice on an Sitagliptin phosphate diet. This is achieved by a positive effect on the regulation of hyperglycemia, potentially through prolongation of islet graft survival[4].?The plasma clearance and volume of distribution of Sitagliptin phosphate are higher in rats (40-48 mL/min/kg, 7-9 L/kg) than in dogs (9 mL/min/kg, 3 L/kg); and its half-life is shorter in rats,2 hours compared with 4 hours in dogs[5].
rac-SitagliptinSupplier
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rac-Sitagliptin(823817-56-7)Related Product Information
- Sitagliptin phosphate
- Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate
- (S)-Sitagliptin Phosphate
- Sitagliptin Impurity 34
- Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
- 1,2,4-Triazolo[4,3-a]pyrazine, 7-[3-amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro- 3-(trifluoromethyl)-
- Sitagliptin Defuoro IMpurity 3
- Sitagliptin DeaMino IMpurity 1
- (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one
- Sitagliptin Impurity 1
- Sitagliptin Impurity 26
- Sitagliptin Impurity 14
- Sitagliptin IMpurity
- Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-
- (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid
- 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
- Sitagliptin
- Sitagliptin EP Impurity B