12-DEOXYPHORBOL 13-PHENYLACETATE 20-ACETATE
12-DEOXYPHORBOL 13-PHENYLACETATE 20-ACETATE Basic information
- Product Name:
- 12-DEOXYPHORBOL 13-PHENYLACETATE 20-ACETATE
- Synonyms:
-
- 12-deoxyphorbolphenylacetate-20-acetate
- 3-acetate9a-phenylacetate
- 12-Deoxyphorbol 13-phenylacate 20-acetate
- 12-DEOXYPHORBOL 13-PHENYLACETATE 20-ACETATE
- (1aR)-3-(Acetyloxymethyl)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-1,1,6,8α-tetramethyl-9aα-[(phenylacetyl)oxy]-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
- 12-DPPAA
- 5H-Cyclopropa(3,4)benz(1,2-E)azulen-5-one, 1,1A-alpha,1B-beta,4,4A,7A-alpha,7B,8,9,9A-decahydro-4A-beta,7B-alpha,9A-alpha-trihydroxy-3-(hydroxymethyl)-1,1,6,8-alpha-tetramethyl-, 3-acetate 9A-phenylacetate
- Benzeneacetic acid ,(1ar,1bs,4ar,7as,7br,8R,9as)-3-((acetyloxy)methyl)-1,1A,1B,4,4A,5,7A,7B,8,9-decahydro-4A,7B-dihydroxy-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-E)azulen-9A-yl ester
- CAS:
- 54662-30-5
- MF:
- C30H36O7
- MW:
- 508.6
- Mol File:
- 54662-30-5.mol
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12-DEOXYPHORBOL 13-PHENYLACETATE 20-ACETATE Chemical Properties
- Boiling point:
- 556.46°C (rough estimate)
- Density
- 1.0979 (rough estimate)
- refractive index
- 1.6810 (estimate)
- storage temp.
- -20°C
- form
- oil
- color
- colorless to light yellow
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Safety Information
- Hazard Codes
- T+
- Risk Statements
- 26/27/28-36/37/38
- Safety Statements
- 26-27-36/37/39-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
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12-DEOXYPHORBOL 13-PHENYLACETATE 20-ACETATE Usage And Synthesis
Uses
dPPA/phorbol ester 12-deoxyphorbol 13-phenylacetate 20-acetate (DOPPA) may be used as a potent activator of PKC-β:
- to tre at transfected HT-22 cells to promote phosphorylation of p66Shc
- to tre at HT-22 and B12 cells to study its effects on cell viability
- to tre at neurons and measure primary cortical neurons using the 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay
Biological Activity
dPPA is a phorbol ester th at selectively activates the β isotype of PKC. It is approximately 100-fold more potent for PKC-β than the α, γ or δ isotypes. PKC family members each have specific functions, but PKC-β and δ appear to share similar expression profiles, and both are involved in regulating apoptosis and B cell activation, thus dPPA is a useful tool in determining PKCβ specific signaling events.
12-DEOXYPHORBOL 13-PHENYLACETATE 20-ACETATESupplier
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Aktin Chemicals, Inc.
- Tel
- 028-85159085
- info@aktinchem.com
Energy Chemical
- Tel
- 021-58432009 400-005-6266
- marketing@energy-chemical.com
Aladdin Scientific
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
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