2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol
2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Basic information
- Product Name:
- 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol
- Synonyms:
-
- Jatrorrhizin
- 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol
- 2,9,10-trimethoxy-
- Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-
- Neprotin
- Neprotine
- Yatrorizine
- 5,6-Dihydro-3-hydroxy-2,9,10-trimethoxyberbinium
- CAS:
- 3621-38-3
- MF:
- C20H20INO4
- MW:
- 465.28
- EINECS:
- 222-817-3
- Product Categories:
-
- Alkaloids
- Mol File:
- 3621-38-3.mol
2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Chemical Properties
- Melting point:
- 208～210℃
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Methanol (Slightly, Heated)
- form
- Solid
- color
- Orange
- Stability:
- Hygroscopic
- InChIKey
- MXTLAHSTUOXGQF-UHFFFAOYSA-O
2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Usage And Synthesis
Description
An alkaloid from Mahonia nepalensis DC. (Syn. Berberis nepalensis Spreng), this base is optically inactive and forms garnet-red crystals which decompose on heat_x0002_ing. The base contains 3.5 mole of H20 and still retains 1 mole even or prolonged drying at 100°C in vacuo. The salts are said to be orange or yellow.
Uses
Jatrorrhizine, is an alkaloid extract from the Berberidaceae family of plants displaying antioxidant activity.
Definition
ChEBI: Jatrorrhizine is an alkaloid.
in vivo
Jatrorrhizine (intraperitoneal?injection; 5, 10, 20 mg/kg) can significantly reduce the duration of immobility when compared with vehicle control group in tail suspension test (TST)[2].
| Animal Model: | Male ICR albino mice[2] |
| Dosage: | 5, 10, 20 mg/kg |
| Administration: | Intraperitoneal?injection; 5, 10, 20 mg/kg |
| Result: | Reduced immobility period in tail suspension test. |
target
LDL | P450 (e.g. CYP17) | NOS | COX | 5-HT Receptor | HMG-CoA Reductase
IC 50
AChE
References
Chatterjee., Sci. & Cult., 7,619 (1942)
Chatterjee.,J. Amer. Pharm. Assoc., 33,205,210 (1944)
2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-olSupplier
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2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol(3621-38-3)Related Product Information
- Berberine
- Palmatine
- Resveratrol
- CORYPALMINE, (+)-(P)
- (R)-(+)-Corypalmine
- JATRORRHIZINE HCL(RG)
- Dehydrocorydaline nitrate
- BERBERINE CHLORIDE
- Palmatine chloride hydrate
- BERBERINE ACID SULFATE
- Dehydrocorydaline
- Palmatine chloride
- BERBERINE CHLORIDE DIHYDRATE
- 2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol
- BERBERINE SULFATE TRIHYDRATE
- PALMATINE IODIDE
- AKOS 213-46
- BERBERINE, ACETONE ADDUCT