4-Chloro-6-methoxy-2-(methylthio)pyrimidine Chemical Properties

Melting point:

38-39℃

Boiling point:

288℃

Density 

1.36

refractive index 

1.

Flash point:

128℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-2.26±0.30(Predicted)

InChI

InChI=1S/C6H7ClN2OS/c1-10-5-3-4(7)8-6(9-5)11-2/h3H,1-2H3

InChIKey

FNYLFWGITLMOHA-UHFFFAOYSA-N

SMILES

C1(SC)=NC(OC)=CC(Cl)=N1

Safety Information

Risk Statements 

22

Safety Statements 

36/37

HS Code 

29335990

4-Chloro-6-methoxy-2-(methylthio)pyrimidine Usage And Synthesis

Chemical Properties

White solid

Uses

4-chloro-6-methoxy-2-(methylthio)pyrimidine is a versatile scaffold and can undergo Suzuki-Miyaura coupling to afford 4-aryl-6-methoxy-2-(methylthio)pyrimidines, as well as amine or alcohol displacement of the chloride, oxidation to sulfone, and condensation reactions to give polycyclic systems][1].

References

[1] A. Kalogirou, P. Koutentis. “4-Chloro-6-ethoxy-2-(methylthio)pyrimidine.” Molbank 2017 1 (2016).

4-Chloro-6-methoxy-2-(methylthio)pyrimidine(89466-42-2)Related Product Information

• Propylthiouracil
• 4-Chloropyrimidine
• 4-Chloro-2-methylthiopyrimidine
• 6-CHLORO-4-ETHOXY-2-METHYLMERCAPTOPYRIMIDINE
• 4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE
• 4-Chloro-6-methoxy-2-(methylthio)pyrimidine