4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE Chemical Properties

Melting point:

90-91℃

Boiling point:

405.1±48.0 °C(Predicted)

Density 

1.449

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-6.47±0.30(Predicted)

Appearance

White to off-white Solid

Safety Information

Safety Statements 

24/25

HS Code 

29339900

4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE Usage And Synthesis

Chemical Properties

White solid

Synthesis

General method: 6-methoxy-2-methylthio-4-chloropyrimidine (5 mmol), tetrabutylammonium bromide (0.16 g, 0.5 mmol, 10 mol%) were mixed with acetone (20 mL) at room temperature and stirred. An aqueous solution of Oxone (12.5 mmol, 2.5 eq.) was slowly added (20 mL) with vigorous stirring. After 4-6 hours of reaction, complete consumption of the feedstock was confirmed by TLC monitoring. The reaction mixture was filtered through a Brewer's funnel and the resulting solid product was washed with water and dried to give 4-chloro-6-methoxy-2-methylsulfonylpyrimidine. The yield, melting point and spectral data of the product are shown below.

References

[1] Synthetic Communications, 2018, vol. 48, # 6, p. 714 - 720
[2] Patent: US5599770, 1997, A
[3] Patent: US5723412, 1998, A

4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE(89466-55-7)Related Product Information

• 2-Chloro-4-ethoxy-6-methyl-pyrimidine
• 5-fluoro-2-(Methylsulfonyl)pyriMidine
• 3-Methyl-1,3-butanediaMine
• Ethyl (2-amino-4-hydroxy-6-methyl-5-pyrimidinyl)acetate
• (2,4,6-TrichloropyriMidin-5-yl)Methanol
• 4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE
• 4-Chloro-6-methoxy-2-(methylthio)pyrimidine
• 4-Chloro-2-(methylsulfonyl)pyrimidine