4-Chloro-2-(methylsulfonyl)pyrimidine Chemical Properties

Melting point:

87-89 °C

Boiling point:

371.2±34.0 °C(Predicted)

Density 

1.486

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-4.77±0.20(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C5H5ClN2O2S/c1-11(9,10)5-7-3-2-4(6)8-5/h2-3H,1H3

InChIKey

BWVZLXTZQHILRC-UHFFFAOYSA-N

SMILES

C1(S(C)(=O)=O)=NC=CC(Cl)=N1

Safety Information

Risk Statements 

20/21/22

Safety Statements 

36/37

HS Code 

29335990

4-Chloro-2-(methylsulfonyl)pyrimidine Usage And Synthesis

Uses

4-Chloro-2-methanesulfonylpyrimidine is a pyrimidine heterocyclic compound with high reactivity and broad application prospects in the fields of medicine, pesticides, dyes and pigments, and materials science.

Chemical Properties

White solid

Synthesis

General procedure for the synthesis of 4-chloro-2-(methylsulfonyl)pyrimidine from 2-methylthio-4-chloropyrimidine: 2-methylthio-4-chloropyrimidine (7.25 mL, 62.3 mmol) and 95% ethanol (100 mL) were added to a 250-mL single-necked flask, and the mixture was cooled to 0 °C under magnetic stirring. 30% hydrogen peroxide (14.4 mL, 187 mmol) and ammonium molybdate tetrahydrate (2.18 g, 1.87 mmol) were slowly added dropwise. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirred overnight under nitrogen protection. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure, followed by evaporation with the addition of water (200 mL). The resulting product was dried with anhydrous sodium sulfate, filtered and concentrated, and finally purified by silica gel column chromatography to give 10.2 g of white solid product in 85.7% yield.

References

[1] Organic Letters, 2011, vol. 13, # 19, p. 5000 - 5003
[2] Journal of Organic Chemistry, 2003, vol. 68, # 13, p. 5388 - 5391
[3] Patent: CN108947974, 2018, A. Location in patent: Paragraph 0122; 0125; 0127-0129
[4] Heterocycles, 1985, vol. 23, # 3, p. 611 - 616
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1146 - 1157

4-Chloro-2-(methylsulfonyl)pyrimidine(97229-11-3)Related Product Information

• Chlorosulfonyl isocyanate
• Epichlorohydrin
• MCPA SODIUM
• Pyrimidine
• Chloroacetic acid
• Difluorochloromethane
• 4-CHLORO-2-METHANESULFONYL-6-METHOXY-PYRIMIDINE
• 5-BROMO-4-CHLORO-2-METHANESULFONYL-PYRIMIDINE
• 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
• 4-chloro-6-cyclopropyl-2-(methylsulfonyl)pyrimidine
• 4-CHLORO-2-(METHYLSULFONYL)-6,7,8,9-TETRAHYDRO-5H-PYRIMIDO[4,5-E][1,4]DIAZEPIN-5-ONE
• PYRIMIDINE, 4,6-DICHLORO-5-METHYL-2-(METHYLSULFONYL)-
• 4-CHLORO-6-METHYL-2-(METHYLSULFONYL)PYRIMIDINE
• MCPA SOLUTION 100 NG/MYL IN ACETONITRIL&
• 4-Chloro-2-(methylsulfonyl)pyrimidine
• 4-chloro-2-(methylsulfonyl)-5-phenylpyrimidine
• 4-CHLORO-2-[(4-METHYLBENZYL)SULFONYL]-5,6,7,8-TETRAHYDROQUINAZOLINE