Derrone
Derrone Basic information
- Product Name:
- Derrone
- Synonyms:
-
- 3-(4-Hydroxyphenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
- Derrone
- 5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
- 4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-
- 5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-4H,8H-pyrano[2,3-f]chromen-4-one
- CAS:
- 76166-59-1
- MF:
- C20H16O5
- MW:
- 336.34
- Mol File:
- 76166-59-1.mol
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Derrone Chemical Properties
- Boiling point:
- 584.1±50.0 °C(Predicted)
- Density
- 1.368±0.06 g/cm3(Predicted)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- powder
- pka
- 6.47±0.40(Predicted)
- color
- Yellow
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Derrone Usage And Synthesis
Uses
Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity[1][2].
target
Antifection
References
[1] Hoang NT, et al. In Vitro Characterization of Derrone as an Aurora Kinase Inhibitor. Biol Pharm Bull. 2016 Jun 1;39(6):935-45. DOI:10.1248/bpb.b15-00835
[2] Kang MJ, et al. Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells. PLoS One. 2019 Jun 19;14(6):e0218659. DOI:10.1371/journal.pone.0218659
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