KURARINONE
KURARINONE Basic information
- Product Name:
- KURARINONE
- Synonyms:
-
- KURARINONE
- Kurarinon
- Marini
- 4H-1-Benzopyran-4-one,2-(2,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-5-methoxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-,(2S)-
- 2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-5-methoxy-8-[5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
- Kurarinone >=98% (HPLC)
- 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(5-methyl-2-prop-1-en-2-ylhex-4-enyl)-2,3-dihydrochromen-4-one
- (S)-2-(2,4-Dihydroxyphenyl)-7-hydroxy-5-methoxy-8-((R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)chroman-4-one
- CAS:
- 34981-26-5
- MF:
- C26H30O6
- MW:
- 438.51
- EINECS:
- 233-305-4
- Mol File:
- 34981-26-5.mol
KURARINONE Chemical Properties
- Melting point:
- 117-119℃
- Boiling point:
- 651.4±55.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 7.49±0.40(Predicted)
- color
- Light yellow to yellow
KURARINONE Usage And Synthesis
Definition
ChEBI: (2S)-(-)-kurarinone is a trihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 7, 2' and 4', a lavandulyl group at position 8 and a methoxy group at position 5. Isolated from the roots of Sophora flavescens, it exhibits cytotoxicity against human myeloid leukemia HL-60 cells. It has a role as a metabolite and an antineoplastic agent. It is a trihydroxyflavanone, a monomethoxyflavanone and a member of 4'-hydroxyflavanones. It is functionally related to a (2S)-flavanone.
Biological Activity
Kurarinone, a flavonoid isolated from Sophora flavescens, inhibits the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting the differentiation of Th1 and Th17 cells.
Physiological effects
Kurarinon has an anti-endothelial cell proliferative activity, and it has a significant inhibitory effect on endothelial cell proliferation with a median inhibitory concentration (IC50) of 12ug/ml.
KURARINONESupplier
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- 025-83697070
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- 0871-65217109 13211707573;
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- +86-028-82633397 18982077548
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- 021-61552785
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- 021-51320588
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KURARINONE(34981-26-5)Related Product Information
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- 2'-HYDROXYFLAVANONE
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- 2,3-Dihydro-7-hydroxy-5-methoxy-2-phenyl-4H-1-benzopyran-4-one
- KURARINONE
- 4-(2-ETHOXYPHENYL)-2-METHYL-1-BUTENE
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- 5-Methoxyflavanone