2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid CAS#: 890842-28-1

ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid

Basic information Safety Supplier Related

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid Basic information

Product Name:

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid

Synonyms:

GSK650394 (Free base)
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid
GSK 650394
SGK inhibitor GS650394
CS-1142
Benzoic acid, 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-
6-O-α-D-Glucopyranosyl-D-glucose
GSK 650394, 10 mM in DMSO

CAS:

890842-28-1

MF:

C25H22N2O2

MW:

382.45

Product Categories:

Inhibitors

Mol File:

890842-28-1.mol

Less

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid Chemical Properties

storage temp.: room temp
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige
InChI: 1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
InChIKey: WVSBGSNVCDAMCF-UHFFFAOYSA-N
SMILES: [nH]1c2ncc(cc2c(c1)c4cc(c(cc4)C(=O)O)C5CCCC5)c3ccccc3

Less

Safety Information

WGK Germany: 3
Storage Class: 11 - Combustible Solids

Less

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid Usage And Synthesis

Uses

GSK-650394 has been used as a serum and glucocorticoid-activated kinase (SGK1) inhibitor.

Definition

ChEBI: 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid is a phenylpyridine.

Biochem/physiol Actions

GSK-650394 has an IC50 value of 62nM for serum and glucocorticoid-activated kinase-1 (SGK1) and 103nM for SGK2. It has an ability to stop viral replication at concentrations that are nontoxic to cells.

in vivo

GSK650394 (1, 10, and 30 μM, 10 μL/rat, intrathecally) dose-dependently prevents CFA-induced pain behavior and the associates SGK1 phosphorylation, GluR1 trafficking, and protein-protein interactions at 1 day after CFA administration^[3]. GSK650394 at concentrations of 10, 30, and 100 nM (10 μL), but not vehicle solution (SNL 3D+Veh and SNL 7D+Veh, respectively), dose-dependently increases the withdrawal latency of the ipsilateral hindpaw at 1-3 and 1-5 h after injection at days 3 and 7 postsurgery (SNL 3D+GSK and SNL 7D+GSK, respectively). GSK650394 (from day 0 to 6 postsurgery; 100 nM, 10 μL, i.t.) administration alleviates SNL-induced allodynia at days 3, 5, and 7 postsurgery in SNL animals^[4].

IC 50

SGK1

storage

Store at RT

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacidSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Email: info@chemexpress.com

MedChemexpress LLC

Tel: 021-58955995
Email: sales@medchemexpress.cn

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com

Less