ROR gamma-t-IN-1 Chemical Properties

Boiling point:

617.1±55.0 °C(Predicted)

Density 

1.434±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF:3.0(Max Conc. mg/mL);5.64(Max Conc. mM)
DMSO:68.33(Max Conc. mg/mL);128.36(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.56(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);93.92(Max Conc. mM)

form 

A crystalline solid

pka

12.33±0.70(Predicted)

color 

White to off-white

ROR gamma-t-IN-1 Usage And Synthesis

Description

GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor''s putative ligand binding domain without exerting significant effects on DNA binding. It inhibits the expression of IL-17 (at 0.5 μM) in naïve CD4⁺ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.

ROR gamma-t-IN-1(1426802-50-7)Related Product Information

• GSK8612
• 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
• 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone
• GSK8612
• GSK6853
• 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid
• GSK620
• GSK591
• GSK5959
• GSK872