ML167 Chemical Properties

Boiling point:

531.8±45.0 °C(Predicted)

Density 

1.335±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO: soluble10mg/mL, clear

form 

powder

pka

13.84±0.10(Predicted)

color 

off-white to gray to brown

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

InChI

1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22)

InChIKey

ROCFOIBAEVAOLQ-UHFFFAOYSA-N

SMILES

N(Cc4[o]c(cc4)C)c1ncnc2c1cc(cc2)c3[o]c(cc3)CO

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

46

WGK Germany 

3

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

ML167 Usage And Synthesis

Description

ML167 (1285702-20-6) is a highly selective cell permeable inhibitor of Cdc2-like kinase 4 (Clk4) – IC50?= 136nM. It displays at least 10-fold greater selectivity over the related kinases Clk1(1.52 μM), Clk2(1.65μM), Clk3(>10μM), Dyrk1A(>10μM), and Dyrk1B(4.4 μM).

Uses

ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B[1].

Definition

ChEBI: [5-[4-[(5-methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol is a member of quinazolines.

target

Clk4

IC 50

CLK4: 136 nM (IC₅₀); CLK1: 1522 nM (IC₅₀); CLK2: 1648 nM (IC₅₀); DYRK1B: 4420 nM (IC₅₀); CDK3: ＞10000 nM (IC₅₀); DYRK1A: ＞10000 nM (IC₅₀)

References

[1] An inhibitor of the Cdc2-like kinase 4 (Clk4); Probe Reports from the NIH Molecular Libraries Program

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