Bendamustine Chemical Properties

Boiling point:

585.2±50.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

-20°C, protect from light

solubility 

DMSO : 100 mg/mL (279.13 mM; Need ultrasonic)

pka

4.50±0.10(Predicted)

form 

Solid

color 

White to off-white

InChI

InChI=1S/C16H21Cl2N3O2/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23/h5-6,11H,2-4,7-10H2,1H3,(H,22,23)

InChIKey

YTKUWDBFDASYHO-UHFFFAOYSA-N

SMILES

C1(CCCC(O)=O)N(C)C2=CC=C(N(CCCl)CCCl)C=C2N=1

Safety Information

Hazardous Substances Data

16506-27-7(Hazardous Substances Data)

Bendamustine Usage And Synthesis

Uses

Treatment of hematologic cancer, especially non-Hodgkin’s lymphoma.

Definition

ChEBI: Bendamustine is a member of benzimidazoles.

brand name

Ribomustine (Amcis AG, Switzerland).

in vivo

Enzyme inhibitor

This nitrogen mustard and anticancer drug (FWfree-acid = 358.26 g/mol; CAS 16506-27-7), also known by its code name SDX-105, its trade names Treanda?, Treakisym?, Ribomustin?, and Levact?, as well as by its systematic name 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2- yl]butanoic acid, is a relatively nonspecific DNA alkylating agent that causes intra- and inter-strand cross-links. Bendamustine is used in the treatment of chronic lymphocytic leukemia (CLL), Hodgkin’s disease, nonHodgkin’s lymphoma, multiple myeloma and lung cancer. Pharmacokinetics: After intravenous infusion, >95% of the drug becomes protein-bound, mainly to albumin; however, only free bendamustine is active. Bendamustine is metabolized by liver cytochrome p450, and elimination (renal) is biphasic, with an initial half-life of 6–10 minutes and a terminal half-life of approximately 30 minutes.

Bendamustine(16506-27-7)Related Product Information

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