Closantel Chemical Properties

Melting point:

217.8°

Boiling point:

590.5±50.0 °C(Predicted)

Density 

1.8759 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml

pka

5.99±0.48(Predicted)

form 

Solid

color 

White to off-white

CAS DataBase Reference

57808-65-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

RIDADR 

2811

WGK Germany 

3

RTECS 

CV2444250

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

A veterinary drug for the treatment of fluke and nematode infestations. In 1993, some was included in a batch of donated drugs sent to Lithuania. Attempts to match the product with the names of other medicines on accompanying literature resulted in its misidentification as a treatment for endometriosis. Eleven women lost their eyesight; though this has since returned, they were left with eye pain and are unable to work.

MSDS

• Language:English Provider:N-[5-Chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid

Closantel Usage And Synthesis

Description

Closantel is a kind of synthetic anti parasitic agent which is actively against liver fluke, bloodsucking nematodes and larval stages of some arthropods in sheep and cattle. Its mechanism of action is through decoupling the mitochondrial oxidative phosphorylation, thus inhibiting the production of ATP. Therefore, it inhibit their energy generation of the parasite, causing their death. It is mainly used for the treatment and prevention of several infections caused by many kinds of parasites such as Fasciola hepatica, Fasciola gigantica, Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum and Strongyloides papillosus in cattle and sheep.

References

http://www.interchemie.com/veterinary-medicines/closan-50.html

Chemical Properties

White to light yellow powder

Uses

antianginal, antihypertensive

Definition

ChEBI: N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide is an aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively. It is a nitrile, a member of phenols, an organoiodine compound, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.

Closantel(57808-65-8)Related Product Information

• CHLOROPHOSPHONAZO III
• Cyhalothrin
• Cyhalothrin
• Niclosamide ethanolamine salt
• Niclosamide
• theta-Cypermethrin
• BETA-CYPERMETHRIN
• Oxyclozanide
• 2-(4-Amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile
• 2-HYDROXY-5-IODO-BENZALDEHYDE
• 2-(2-Chlorophenyl)acetonitrile
• 3-Methylbenzyl cyanide
• 3,5-DIIODOSALICYLALDEHYDE
• Difluorochloromethane
• 3-Iodobenzylamine hydrochloride
• (4-AMINOPHENYL)PHENYLACETONITRILE HYDROCHLORIDE,97%
• 2-(4-aminophenyl)propiononitrile
• closantel sodium salt,CLOSANTEL SODIUM,CLOSANTEL(NA)