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Oxyclozanide

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Oxyclozanide Basic information

Product Name:
Oxyclozanide
Synonyms:
  • 3,3’,5,5’,6-pentachloro-2,2’-dihydroxybenzanilide
  • 2,2’-dihydroxy-3,3’,5,5’,6-pentachlorobenzanilide
  • 2,3,5-trichloro-n-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxy-benzamid
  • 2,3,5-TRICHLORO-N-(3,5-DICHLORO-2-HYDROXYPHENYL)-6-HYDROXYBENZAMIDE
  • OXYCLOZANIDE BPV
  • BPV OXYCLOZANIDE BPV
  • Oxycloxanide
  • OXYCLOZANIDE B.P
CAS:
2277-92-1
MF:
C13H6Cl5NO3
MW:
401.46
EINECS:
218-904-0
Mol File:
2277-92-1.mol
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Oxyclozanide Chemical Properties

Melting point:
77-81C
Boiling point:
215C
Density 
1.6274 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
5.07±0.50(Predicted)
color 
White to off-white
Water Solubility 
29mg/L(25 ºC)
InChI
InChI=1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)
InChIKey
JYWIYHUXVMAGLG-UHFFFAOYSA-N
SMILES
C(NC1=CC(Cl)=CC(Cl)=C1O)(=O)C1=C(O)C(Cl)=CC(Cl)=C1Cl
CAS DataBase Reference
2277-92-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn;N,N,Xn,Xi
Risk Statements 
22-50/53-36/37/38
Safety Statements 
60-61-36-26
RIDADR 
UN 3077
WGK Germany 
3
RTECS 
CV8576000
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Oxyclozanide Usage And Synthesis

Uses

Anthelmintic

in vivo

Oxyclozanide (15 mg/kg (sheep), 10 mg/kg (cattle); oral administration) shows antiparasitic effectiveness in sheep and cattle[1]. Oxyclozanide (1500-5000 mg/kg; oral administration, once) induces multiple toxic symptoms in acute toxicity test of rats[2].

Animal Model:Healthy male and female Wistar rats (100-150 g)[2]
Dosage:5000, 3690, 2730, 2025 and 1500 mg/kg
Administration:Oral administration; 5000, 3690, 2730, 2025 and 1500 mg/kg; once
Result:Induced toxic symptoms of pression, rough hair, inappetence and cyanotic lips, limbs and tail. Induced swelling spleen, bleeding spots in the liver and swelling stomachs at high-dose group.

IC 50

Schistosome

OxyclozanideSupplier

Wuhan Xinru Chemical Co., Ltd. Gold
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15927387915 15337108568
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Tai 'an Jiangzhou Biotechnology Co., LTD Gold
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1385-13854830759 13854830759
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Shanghai Aladdin Biochemical Technology Co.,Ltd. Gold
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400-6206333 13167063860
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Hubei Yangyi Xinsheng Biological Medicine Co., LTD Gold
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15927387803; 15927387803
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Aemon Chemical
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0086-755-86198205
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acinfo@aemonchem.com