ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE Chemical Properties

Melting point:

243-245 °C(lit.)

storage temp. 

Store below +30°C.

form 

solid

color 

White to Light yellow to Light orange

Water Solubility 

Soluble in hot water.

Sensitive 

Hygroscopic

CAS DataBase Reference

1235-21-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-S24/25-S22-60-37-26

WGK Germany 

3

RTECS 

TA1841000

F 

3

HS Code 

29319019

Toxicity

mouse,LD50,intravenous,56mg/kg (56mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01535,

MSDS

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ACETONYLTRIPHENYLPHOSPHONIUM CHLORIDE Usage And Synthesis

Chemical Properties

WHITE TO SLIGHTLY BEIGE FINE CRYSTALLINE POWDER

Uses

Acetonyltriphenylphosphonium chloride is used to investigate the antimycobacterial activities of Me alkenyl quinolones. It is used as a reactant for synthesis of unsaturated esters and ketones containing multiple aromatic and heteroaromatic rings using Suzuki coupling - Wittig olefination.

Uses

Used to investigate the antimycobacterial activities of Me alkenyl quinolones

Reactant for synthesis of:

• Unsaturated esters and ketones containing multiple aromatic and heteroaromatic rings using Suzuki coupling - Wittig olefination
• Fused oxygen and nitrogen heterocycles via regioselective cyclocondensation

Purification Methods

Recrystallise it from CHCl3/*C6H6/pet ether (b 60-80o) or by dissolving it in CHCl3 and pouring it into dry Et2O. max nm() 255(3,600), 262(3,700), 268(4,000) and 275(3,100). The iodide salt crystallises from H2O and has m 207-209o. [Ramirez & Dershowitz J Org Chem 22 41 1957.] Itisan IRRITANT and is hygroscopic. When shaken with a 10% aqueous solution of Na2CO3 (8hours) it gives acetylmethylene triphenyl phosphorane which is recrystallised from MeOH/H2O and after drying at 70o/0.1mm has m 205-206o. UV: nm() 268 (6600), 275 (6500) and 288 (5700), IR: max 1529 (s), 1470 (m), 1425 (s), max 1374 (m), 1105 and 978 (s) (cm-1). [Ramirez & Dershowitz J Org Chem 22 41, 44 1957, Beilstein 16 H 761, 16 II 373.]

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