Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate Chemical Properties

Melting point:

154-156 °C (dec.)(lit.)

Density 

1.438 at 20℃

vapor pressure 

0-0Pa at 20-50℃

storage temp. 

2-8°C

solubility 

methanol: 25 mg/mL, clear

form 

Fine Crystalline Powder

color 

White to off-white

Sensitive 

Moisture Sensitive

BRN 

3584612

InChI

InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1

InChIKey

BYCLGHOAELJLOF-UHFFFAOYSA-M

SMILES

[P+](ON1N=NC2C=CC=CC1=2)(N1CCCC1)(N1CCCC1)N1CCCC1.[P-](F)(F)(F)(F)(F)F

LogP

-0.3 at 26℃ and pH3.5-3.7

CAS DataBase Reference

128625-52-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

37/38-44-36/37/38

Safety Statements 

26-36-24/25-37/39

RIDADR 

UN 1325 4.1/PG 2

WGK Germany 

3

F 

8-10-21

Hazard Note 

Irritant

HS Code 

29339980

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

One of the most convenient coupling reagents for peptide synthesis without carcinogenic by-products. It replaces BOP reagent. This is especially suitable for solid-phase peptide synthesis, avoids racemization.

Uses

1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.

Uses

Reagent for:
Synthesis of single labeled oligonucleotides that fluoresce upon matched hybridization
Generation of endocrine disruptor chemical binders
Cycloaddition to template-assembled multivalent peptide conjugates

General Description

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate(128625-52-5)Related Product Information

• Bis(2-oxo-3-oxazolidinyl)phosphinic chloride
• DEPBT
• TSTU
• 5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate
• Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate
• Diphenylphosphoryl azide
• 1H-Benzotriazole
• Hexafluorophosphoric acid
• Potassium hexafluorophosphate
• Lithium hexafluorophosphate
• Sodium hexafluorophosphate
• Hexafluorophosphate
• TRIS(DIETHYLAMINO)PHOSPHINE
• 1-Hydroxybenzotriazole hydrate
• 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate
• Hexamethylphosphorous triamide
• Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate