5-bromo-N-(2-morpholin-4-ylethyl)pyridine-3-carboxamide Chemical Properties

Melting point:

107-109 °C

Boiling point:

465.4±45.0 °C(Predicted)

Density 

1.426±0.06 g/cm3(Predicted)

pka

13.70±0.46(Predicted)

form 

Solid

color 

White to off-white

5-bromo-N-(2-morpholin-4-ylethyl)pyridine-3-carboxamide Usage And Synthesis

Uses

WAY-620147 (compound 6) is an N-(2-morpholinoethyl)nicotinamide derivative that inhibits monoamine oxidase (Monoamine Oxidase). WAY-620147 inhibits MAO-A and MAO-B with IC50s of 26 μM and 55 μM, respectively[1].

References

[1] Shi L, et al. Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DOI:10.1016/j.bmc.2009.12.065

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