2-Propylpiperidine Chemical Properties

Melting point:

-2℃

Boiling point:

56-60 °C(Press: 13 Torr)

Density 

0.85 g/mL at 25 °C(lit.)

storage temp. 

Sealed in dry,2-8°C

form 

liquid

pka

pK1:11.24(+1) (25°C,μ=0.5)

color 

, clear colorless to yellow-green

CAS DataBase Reference

3238-60-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25-40

Safety Statements 

22-36/37/39-45

RIDADR 

UN 2810 6.1/PG 2

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

Toxicity

Piperidine alkaloid obtained from poison hemlock, Conium maculatum. Alkaline, steam volatile liquid (b.p. 167_x0003_C), mousy odor. Darkens and polymerizes in air. It can be reduced at high temperature with HI to n-octane and oxidized to pyridine-1-carboxylic acid. The hydrochloride is used as an antispasmodic.

MSDS

• Language:English Provider:SigmaAldrich

2-Propylpiperidine Usage And Synthesis

Chemical Properties

Colorless liquid; darkens on exposure tolight and air; polymerizes; boils at 166°C(330.8°F); melts at -2°C (28.4°F); alkaline, pKa 3.1; density 0.845 at 20°C (68°F);slightly soluble in water and chloroform,readily soluble in most organic solvents.

Uses

Coniine is present in all parts of the plantpoison hemlock (Conium maculatum). It isthe first alkaloid to be synthesized and structure determined. Because of its high toxicity,its clinical application is very limited.

Synthesis Reference(s)

Tetrahedron Letters, 26, p. 4633, 1985 DOI: 10.1016/S0040-4039(00)98771-9

Health Hazard

Coniine is a highly toxic alkaloid. Thetoxic symptoms from ingestion are weakness,drowsiness, nausea, vomiting, muscle contraction, and labored breathing. A high dosecan cause convulsions, cyanosis, asphyxia,and death. Chronic ingestion of coniine produced adverse reproductive effects and spe cific developmental abnormalities in cattles.LD50 value, oral (mice): 100 mg/kg.

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