Basic information Safety Supplier Related

METHANTHELINE BROMIDE

Basic information Safety Supplier Related

METHANTHELINE BROMIDE Basic information

Product Name:
METHANTHELINE BROMIDE
Synonyms:
  • ammonium,diethyl(2-hydroxyethyl)methyl-,bromide,xanthene-9-carboxylate
  • asabaine
  • METHANETHELINIUMBROMIDE
  • Bantosal
  • frenogastrico
  • gastrosedan
  • mantheline
  • metantyl
CAS:
53-46-3
MF:
CH3-
MW:
15.03452
EINECS:
2001760
Mol File:
53-46-3.mol
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METHANTHELINE BROMIDE Chemical Properties

Melting point:
175-176°
Density 
1.3380 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Dark Orange to Very Dark Orange
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Safety Information

Toxicity
LD50 i.p. in mice: 76 mg/kg (Hambourger)
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METHANTHELINE BROMIDE Usage And Synthesis

Uses

Ulcine is a strong muscarinic receptor blocking drug used in the treatment of overactive bladder syndrome, hypersalivation and hyperhidrosis.

Uses

METHANTHELINE BROMIDE is a strong muscarinic receptor blocking drug used in the treatment of overactive bladder syndrome, hypersalivation and hyperhidrosis.

Definition

ChEBI: Methantheline bromide is a member of xanthenes.

General Description

Methanthelinebromide, diethyl(2-hydroxyethyl)methylammonium bromidexanthene-9-carboxylate (Banthine Bromide), is awhite, slightly hygroscopic, crystalline salt that is solublein water to produce solutions with a pH of about 5.Aqueous solutions are not stable and hydrolyze in a fewdays. The bromide form is preferable to the very hygroscopicchloride.
Among the conditions for which methantheline bromideis indicated are gastritis, intestinal hypermotility, bladderirritability, cholinergic spasm, pancreatitis, hyperhidrosis,and peptic ulcer, all of which are manifestations ofparasympathotonia.

Clinical Use

Methantheline bromide, introduced in 1950, is a potent anticholinergicagent and acts at the nicotinic cholinergic receptors of thesympathetic and parasympathetic systems, as well as at themyoneural junction of the postganglionic cholinergic fibers.Like other quaternary ammonium drugs, methantheline bromideis absorbed incompletely from the GI tract.

METHANTHELINE BROMIDESupplier

J & K SCIENTIFIC LTD.
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Sinopharm Chemical Reagent Co,Ltd.
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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Dayang Chem (Hangzhou) Co.,Ltd.
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BOC Sciences
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