2-HYDROXY-3-METHYLBUTYRIC ACID Chemical Properties

Melting point:

86-87 °C (lit.)

Boiling point:

120-125 °C(Press: 17 Torr)

Density 

1.136±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in dimethyl sulfoxide and methanol.

form 

Solid

pka

3.87±0.16(Predicted)

color 

White

LogP

0.013 (est)

CAS DataBase Reference

4026-18-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-10

MSDS

• Language:English Provider:SigmaAldrich

2-HYDROXY-3-METHYLBUTYRIC ACID Usage And Synthesis

Chemical Properties

White Solid

Uses

2-Hydroxy-3-methylbutyric Acid is a α-hydroxylated butyric acid derivative used as a marker in chemical diagnosis of organic aciduria and other inborn errors. 2-Hydroxy-3-methylbutyric Acid is also us ed as a metabolomic biomarkers in preeclampsia.

Uses

2-Hydroxy-3-methylbutyric acid is employed as internal standard for analysis of ethylene glycol (EG) and γ-hydroxybutyrate (GHB) in whole blood.

Definition

ChEBI: A valine derivative that is valine in which the amino group has been replaced by a hydroxy group.

General Description

Chiral resolution of 2-hydroxy-3-methylbutyric acid without derivatization has been studied by capillary electrophoresis using 2-hydroxypropyl-β-cyclodextrin.

2-HYDROXY-3-METHYLBUTYRIC ACID(4026-18-0)Related Product Information

• MUCONOMYCIN A
• RETRORSINE
• 2-HYDROXY-3-METHYLBUTYRIC ACID
• Ethyl 3-methyl-3-phenylglycidate
• Oxyphenonium bromide
• AGARIC ACID
• DL-Pantolactone
• DL-ISOCITRIC ACID LACTONE
• TETRAHYDROFURAN-2,3,4,5-TETRACARBOXYLIC ACID
• Methyl cyclopentylphenylglycolate
• METHYL ALPHA IONONE GLYCIDATE
• (S)-(+)-2-HYDROXY-3-METHYLBUTYRIC ACID
• Isocitric acid trisodium salt
• (1S)-(-)-Camphanic acid
• alpha-Cyclopentylmandelic acid
• D-(-)-PANTOLACTONE
• (S)-(+)-2-Amino-3-hydroxy-3-methylbutanoic acid
• (2R)-2-Hydroxy-3-methylbutyric acid