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RETRORSINE

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RETRORSINE Basic information

Product Name:
RETRORSINE
Synonyms:
  • BETA-LONGILOBINE
  • 12,18-DIHYDROXYSENECIONAN-11,16-DIONE
  • RETRORSIN
  • RETRORSINE
  • 16-dione,12,18-dihydroxy-senecionan-1
  • 5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-hydroxymethyl-5-3-ethylidene-4
  • cis-retronecicacidesterofretronecine
  • methyl(1,6)dioxacyclododeca(2,3,4-gh)pyrrolizidine-2,7-dione
CAS:
480-54-6
MF:
C18H25NO6
MW:
351.39
EINECS:
610-403-9
Mol File:
480-54-6.mol
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RETRORSINE Chemical Properties

Melting point:
208-211 °C (lit.)
alpha 
D18 -17.6° (c = 1.99 in ethanol)
Boiling point:
485.2°C (rough estimate)
Density 
1.32±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5100 (estimate)
storage temp. 
2-8°C
pka
12.00±0.40(Predicted)
form 
Solid
color 
White to off-white
Merck 
13,8253
InChIKey
BCJMNZRQJAVDLD-VMOBWIEOSA-N
CAS DataBase Reference
480-54-6
IARC
3 (Vol. 10, Sup 7) 1987
EPA Substance Registry System
Retrorsine (480-54-6)
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Safety Information

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
22-36/37/39-45
RIDADR 
1544
WGK Germany 
3
RTECS 
VH7525000
HazardClass 
6.1(a)
PackingGroup 
II
Hazardous Substances Data
480-54-6(Hazardous Substances Data)
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RETRORSINE Usage And Synthesis

Uses

Retrorsine-D4 is a labelled analogue of Retrorsine (R279000). Retrorsine is a pyrrolizidine alkaloid that blocks the hepatocyte cell cycle, ultimately affecting hepatocyte proliferative capacity.

Definition

ChEBI: Retrorsine is a macrolide.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. hhtation data reported. When heated to decomposition it emits toxic fumes of NOx.

RETRORSINESupplier

Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Email
tauto@tautobiotech.com
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Email
sales@chem-strong.com
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Email
sales@reading-chemicals.com
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