Basic information Safety Supplier Related

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH

Basic information Safety Supplier Related

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Basic information

Product Name:
H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
Synonyms:
  • H-RRRRRRRRR-NH2
  • RRRRRRRRR
  • (ARG)9
  • H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
  • Nonaarginine
  • H(-Arg)9-OH, Nonaarginine
  • (Arg)9 peptide
  • Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
CAS:
143413-47-2
MF:
C54H110N36O10
MW:
1423.69
Product Categories:
  • peptide
Mol File:
143413-47-2.mol
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H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Chemical Properties

Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
Sequence
H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH
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H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Usage And Synthesis

Biological Activity

(Arg)9 (Nona-L-arginine; Peptide R9) is a cell-permeable polypeptide with IC50 value of 0.78 μM for neuroprotection in a glutamate model experimental model.

in vitro

Poly-arginine (eg (Arg)9) and arginine-rich peptides (eg TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. It provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC 50 =0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC 50 =0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC 50 =6 μM).

in vivo

(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after reduces permanent middle cerebral artery occlusion (MCAO) infarct volume .

target

IC50: 0.78 μM (neuroprotection)

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OHSupplier

Beijing HwrkChemical Technology Co., Ltd
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010-89508211 18501085097
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sales.bj@hwrkchemical.com
GL Biochem (Shanghai) Ltd
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21-61263452 13641803416
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ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
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