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Salvianolic acid

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Salvianolic acid Basic information

Product Name:
Salvianolic acid
Synonyms:
  • (2R)-3-(3,4-Dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid
  • SALVIANOLIC ACID A 98.0% BY HPLC
  • Danphenolic acid A
  • (R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acryloyl)o
  • Salvianolic acid A, froM Salvia Miltiorrhiza
  • (R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acryloyl)oxy)propanoic acid
  • (αR)-α-[[(2E)-3-[2-[(1E)-2-(3,4-Dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid
  • Dan phenolic acid A hydrate
CAS:
96574-01-5
MF:
C26H22O10
MW:
494.45
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • Aromatics
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
96574-01-5.mol
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Salvianolic acid Chemical Properties

Melting point:
164-167°C
Boiling point:
858.7±65.0 °C(Predicted)
Density 
1.580±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: ≥19mg/mL
pka
2.78±0.10(Predicted)
form 
powder
color 
yellow
BRN 
2660108
InChIKey
YMGFTDKNIWPMGF-UCPJVGPRSA-N
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29189900
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Salvianolic acid Usage And Synthesis

Description

Salvianolic acid A is an antioxidant and free radical scavenging compound extracted from S. miltiorrhiza that has been investigated for its cardioprotective and chemopreventative properties. It has been reported to reduce leukocyte-endothelial adherence, as well as inhibit inflammation and matrix metalloproteinases, suppress apoptosis, and reduce lipid peroxidation in damaged cardiac tissue.

Chemical Properties

Yellow Solid

Uses

ISalvianolic acid A (Sal A) and salvianolic acid B (Sal B) were isolated and purified from the crude extract of Salvia miltiorrhiza. Antioxidant activities of Sal A and Sal B were also evaluated and the ABTS results showed that Sal A and Sal B exhibited high total antioxidant activities, their EC50 values were 1.35 0.00 and 1.43 0.01 .mu.g/mL.

Uses

ISalvianolic acid A (Sal A) and salvianolic acid B (Sal B) were isolated and purified from the crude extract of Salvia miltiorrhiza. Antioxidant activities of Sal A and Sal B were also evaluated the ABTS results showed that Sal A and Sal B exhibited high total antioxidant activities, their EC50 values were 1.35 0.00 and 1.43 0.01 .mu.g/mL.

Definition

ChEBI: Salvianolic acid A is a stilbenoid.

General Description

Salvianolic acid A is a phenolic acid, isolated from Danshen, a traditional Chinese medicine, commonly used for the treatment of bone loss, chronic renal failure, hepatocirrhosis, hepatitis, coronary heart disease and cerebrovascular disease.

Biochem/physiol Actions

Salvianolic acid A is cell protective antioxidant originally isolated from Salvia. It has been found to attenuate PDGF-induced ROS formation in hepatic stellate cells and protected against isoproterenol-induced myocardial damage in rats.

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