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Salvianolicacid C

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Salvianolicacid C Basic information

Product Name:
Salvianolicacid C
Synonyms:
  • Salvianolicacid C
  • (alphaR)-alpha-[[(2E)-3-[2-(3,4-Dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid
  • (2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2-propenoyl}oxy)propanoic acid
  • Benzenepropanoic acid, α-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (αR)-
  • Benzenepropanoic acid, a-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-,(aR)-
  • (R,E)-3-(3,4-Dihydroxyphenyl)-2-((3-(2-(3,4-dihydroxyphenyl)-7-hydroxybenzofuran-4-yl)acryloyl)oxy)propanoic acid
  • (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-(3,4-dihydroxypheny...
  • (2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2-propenoyl}oxy)propanoicaci
CAS:
115841-09-3
MF:
C26H20O10
MW:
492.43
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
115841-09-3.mol
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Salvianolicacid C Chemical Properties

Boiling point:
844.2±65.0 °C(Predicted)
Density 
1.570
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in methanol and water
form 
powder
pka
2.76±0.10(Predicted)
color 
Yellow
InChIKey
GCJWPRRNLSHTRY-QKKCHETFNA-N
SMILES
C(O)(=O)[C@H](OC(=O)/C=C/C1=C2C(=C(O)C=C1)OC(C1=CC=C(O)C(O)=C1)=C2)CC1=CC=C(O)C(O)=C1 |&1:3,r|
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Salvianolicacid C Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Salvia miltiorrhiza.

Uses

Salvianoic Acid C is found in Danshen, a well-?known traditional Chinese medicine (TCM) used to treat cardiovascular and cerebrovascular diseases.

Definition

ChEBI: Salvianolic acid C is a member of benzofurans.

in vivo

Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 and 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β and IL-6 levels compared with the model group. The iNOS and COX-2 levels in rat brain cortex and hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex and hippocampus regions. Salvianolic acid C (5, 10 and 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 and NQO1 levels in rat brain cortex and hippocampus[2].

IC 50

CYP2C8: 4.82 μM (Ki); CYP2J2: 5.75 μM (Ki)

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