2'-HYDROXY-6'-METHOXYACETOPHENONE Chemical Properties

Melting point:

58-60 °C(lit.)

Boiling point:

141 °C16 mm Hg(lit.)

Density 

1.158

refractive index 

1.5500 (estimate)

Flash point:

141°C/16mm

storage temp. 

Sealed in dry,Room Temperature

pka

9.79±0.10(Predicted)

form 

solid

color 

Light yellow to yellow

BRN 

1869049

LogP

2.390 (est)

CAS DataBase Reference

703-23-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

N

HS Code 

29145090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2'-HYDROXY-6'-METHOXYACETOPHENONE Usage And Synthesis

Chemical Properties

Yellow crystalline powder

Uses

2''-Hydroxy-6''-methoxyacetophenone is useful in the synthesis of an aminopyrazole compound which is used to treat cancer and inhibits Chk1. 2''-Hydroxy-6''-methoxyacetophenone is also used to prepare 5,?4''-?disubstituted flavones, predicted androgen receptor antagonists and naphthopyrazolyl carbothioamides which are anticancer agents.

Uses

2′-Hydroxy-6′-methoxyacetophenone was used as starting material in the synthesis of 5-methoxyflavaone. It was also used in synthesis of 5,6-dihydroxyflavone.

Preparation

Preparation by reaction of methyl iodide on 2,6-dihydroxyacetophenone with potassium carbonate in boiling acetone (56%).

Definition

ChEBI: 2'-Hydroxy-6'-methoxyacetophenone is an aromatic ketone.

General Description

An organometallic synthetic route to 2′-hydroxy-6′-methoxyacetophenone was reported.

2'-HYDROXY-6'-METHOXYACETOPHENONE(703-23-1)Related Product Information

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