Basic information Safety Supplier Related

SUBSTANCE P

Basic information Safety Supplier Related

SUBSTANCE P Basic information

Product Name:
SUBSTANCE P
Synonyms:
  • RPKPQQFFGLM-NH2
  • RPKPQFFGLM
  • SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE)
  • SUBSTANCE P BOVINE
  • SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11]
  • SUBSTANCE P AMIDE
  • SUBSTANCE P
  • SUBSTANCE P (TYR8)
CAS:
12769-48-1
MF:
C63H98N18O13S
MW:
1347.63
Mol File:
12769-48-1.mol
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SUBSTANCE P Chemical Properties

storage temp. 
-20°C
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SUBSTANCE P Usage And Synthesis

Uses

Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.

Definition

ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).

Mechanism of action

Substance P is an 11-amino-acid neuropeptide belonging to the tachykinin family, mediating its biological actions through activation of G protein–coupled tachykinin (neurokinin-1 [NK1]) receptors. Its proposed physiological roles include inflammation, pain, GI and respiratory function, stress responses, and emesis. Substance P is uniquely associated with the monoamine neurotransmitters, 5-HT and NE.

Clinical Use

The 5-HT neurons coexpress substance P, and the firing of NE neurons is modulated by substance P. Preclinical studies have supported a role of the substance P–NK1 receptor system in stress-related disorders, which has guided the antidepressant development of centrally active NK1 receptor antagonists, such as aprepitant. The NK1 antagonists are generally well tolerated and exhibit less nausea and sexual dysfunction than some currently used antidepressants.

SUBSTANCE PSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
Email
info@hanhongsci.com
Nanjing Leon Biological Technology Co., Ltd.
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17705183659
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sales@njleonbiotech.com
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Email
liugang@njpeptide.com
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com