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CORTICOSTERONE

Basic information Safety Supplier Related

CORTICOSTERONE Basic information

Product Name:
CORTICOSTERONE
Synonyms:
  • 11,12-dihydroxyprogesterone
  • 21-Dihydroxyprogesterone
  • 11BETA,21-DIHYDROXY-PROGESTERONE
  • 11BETA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
  • 11BETA,21-DIHYDROXY-4-PRENENE-3,20-DIONE
  • (11BETA)-11,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE
  • KENDALL'S 'B'
  • KENDALL'S COMPOUND B
CAS:
50-22-6
MF:
C21H30O4
MW:
346.47
EINECS:
200-019-6
Product Categories:
  • Steroids
  • Biochemistry
  • TPI
  • Hydroxyketosteroids
  • Intermediates & Fine Chemicals
  • Hormone Drugs
  • Pharmaceuticals
  • Inhibitors
Mol File:
50-22-6.mol
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CORTICOSTERONE Chemical Properties

Melting point:
179-183 °C(lit.)
alpha 
D15 +223° (c = 1.1 in alc)
Boiling point:
401.19°C (rough estimate)
Density 
1.0413 (rough estimate)
refractive index 
1.4430 (estimate)
Flash point:
9℃
storage temp. 
-20°C
form 
White to tan crystalline powder
optical activity
[α]20/D +223±3°, c = 1% in ethanol
Water Solubility 
240.5mg/L(37 ºC)
Merck 
2538
BRN 
2339601
Stability:
Stable, but light sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference
50-22-6(CAS DataBase Reference)
EPA Substance Registry System
Corticosterone (50-22-6)
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Safety Information

Hazard Codes 
Xi,N,Xn,T,F
Risk Statements 
43-40-39/23/24/25-23/24/25-11
Safety Statements 
36-22-45-36/37-16
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
GM7650000
HS Code 
29372900

MSDS

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CORTICOSTERONE Usage And Synthesis

Chemical Properties

white to light yellow powder

Uses

Glucocorticoid; an intermediate in the biosynthesis of aldosterone, isolated from the adrenal cortex.

Uses

Corticosteroid is an activator of MCR.

Definition

ChEBI: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glan s.

Biological Activity

Endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.

Purification Methods

Purify corticosterone by recrystallisation from Me2CO (trigonal plates), EtOH or isoPrOH. It has UV max at 240nm, and gives an orange-yellow solution with strong fluorescence on treatment with concentrated H2SO4. It is insoluble in H2O but soluble in organic solvents. [Reichstein & Euw Helv Chim Acta 2 1 1197 1938, 2 7 1287 1944; Mason et al. J Biol Chem 114 613 1936; ORD: Foltz et al. J Am Chem Soc 7 7 4359 1955; NMR: Shoolery & Rogers J Am Chem Soc 8 0 5121 1958.] The 21-O-acetyl derivative [1173-26-8] crystallises from Me2CO/Et2O with m 152.5-153o, [] D 20 +195o (c 0.6, Me2CO), and the 21-O-benzoyl derivative crystallises from AcOH/Et2O with m 201-202o [Reichstein Helv Chim Acta 2 0 953 1937]. [Beilstein 8 IV 2907.]

CORTICOSTERONESupplier

ShangHai Vita Chemicals Reagent Co., Ltd. Gold
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021-57120026 13761879068 15221782916
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1852290626@qq.com 3080806090@qq.com
Beijing Jin Ming Biotechnology Co., Ltd. Gold
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010-60605840-
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psaitong@jm-bio.com
Shanghaizehan biopharma technology co., Ltd. Gold
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021-61350663-
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sales@zehanbiopharma.com;
Hubei Nordina Biotechnology Co., Ltd. Gold
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181-6268-7200
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nuodinashengwu@163.com
J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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