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CORTICOSTERONE

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CORTICOSTERONE Basic information

Product Name:
CORTICOSTERONE
Synonyms:
  • 11,12-dihydroxyprogesterone
  • 21-Dihydroxyprogesterone
  • 11BETA,21-DIHYDROXY-PROGESTERONE
  • 11BETA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
  • 11BETA,21-DIHYDROXY-4-PRENENE-3,20-DIONE
  • (11BETA)-11,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE
  • KENDALL'S 'B'
  • KENDALL'S COMPOUND B
CAS:
50-22-6
MF:
C21H30O4
MW:
346.47
EINECS:
200-019-6
Product Categories:
  • Steroids
  • Biochemistry
  • TPI
  • Hydroxyketosteroids
  • Intermediates & Fine Chemicals
  • Hormone Drugs
  • Pharmaceuticals
  • Inhibitors
Mol File:
50-22-6.mol
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CORTICOSTERONE Chemical Properties

Melting point:
179-183 °C(lit.)
alpha 
D15 +223° (c = 1.1 in alc)
Boiling point:
401.19°C (rough estimate)
Density 
1.0413 (rough estimate)
refractive index 
1.4430 (estimate)
Flash point:
9℃
storage temp. 
-20°C
solubility 
Chloroform (Sparingly, Sonicated), Ethanol (Slightly, Sonicated)
form 
White to tan crystalline powder
color 
White to Pale Yellow
optical activity
[α]20/D +223±3°, c = 1% in ethanol
Water Solubility 
240.5mg/L(37 ºC)
Merck 
2538
BRN 
2339601
Stability:
Stable, but light sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference
50-22-6(CAS DataBase Reference)
EPA Substance Registry System
Corticosterone (50-22-6)
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Safety Information

Hazard Codes 
Xi,N,Xn,T,F
Risk Statements 
43-40-39/23/24/25-23/24/25-11
Safety Statements 
36-22-45-36/37-16
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
GM7650000
HS Code 
29372900
Toxicity
An adrenocortical steroid with modest glucocorticoid and mineralocorticoid activity. It is the primary glucocorticoid in the rat.

MSDS

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CORTICOSTERONE Usage And Synthesis

Description

Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors. It is produced in response to ACTH (corticotropic hormone) and is the precursor to aldosterone synthesis. Since the production of glucocorticoids is increased by stress, it is often used as a biomarker of stress. Plasma corticosterone levels have a circadian variation and corticosterone may be important in the regulation of the sleep-wake cycle.

Chemical Properties

white to light yellow powder

Uses

Glucocorticoid; an intermediate in the biosynthesis of aldosterone, isolated from the adrenal cortex.

Uses

Corticosterone: HBC complex has been used:

  • in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity
  • to induce acute stress in mice
  • in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription

Uses

Corticosteroid is an activator of MCR.

Definition

ChEBI: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glan s.

General Description

Corticosterone is a corticosteroid and aldosterone precursor produced in the adrenal glands. Serum corticosterone levels are measured by LC-MS/MS for newborn screening and diagnosis of 11-hydroxylase deficiency.

Biological Activity

Endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.

Biochem/physiol Actions

The complex of corticosterone with 2-hydroxypropyl-β-cyclodextrin (HBC) improves water solubility. HBC is a carrier molecule. Corticosterone is a rodent-specific primary adrenal corticosteroid. It displays affinity towards the glucocorticoid and mineralocorticoid receptors.

target

IL Receptor | TNF-α | AChR

storage

Room temperature

Purification Methods

Purify corticosterone by recrystallisation from Me2CO (trigonal plates), EtOH or isoPrOH. It has UV max at 240nm, and gives an orange-yellow solution with strong fluorescence on treatment with concentrated H2SO4. It is insoluble in H2O but soluble in organic solvents. [Reichstein & Euw Helv Chim Acta 2 1 1197 1938, 2 7 1287 1944; Mason et al. J Biol Chem 114 613 1936; ORD: Foltz et al. J Am Chem Soc 7 7 4359 1955; NMR: Shoolery & Rogers J Am Chem Soc 8 0 5121 1958.] The 21-O-acetyl derivative [1173-26-8] crystallises from Me2CO/Et2O with m 152.5-153o, [] D 20 +195o (c 0.6, Me2CO), and the 21-O-benzoyl derivative crystallises from AcOH/Et2O with m 201-202o [Reichstein Helv Chim Acta 2 0 953 1937]. [Beilstein 8 IV 2907.]

CORTICOSTERONESupplier

Beijing Jin Ming Biotechnology Co., Ltd. Gold
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Shanghaizehan biopharma technology co., Ltd. Gold
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J & K SCIENTIFIC LTD.
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006608290; 18621169109
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