3-Thienylmethylamine Chemical Properties

Boiling point:

102°C (15 mmHg)

Density 

1.130

refractive index 

1.5660

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

clear liquid

pka

9.57±0.29(Predicted)

color 

Colorless to Light yellow

Water Solubility 

Slightly soluble in water.

Sensitive 

Air Sensitive

InChI

InChI=1S/C5H7NS/c6-3-5-1-2-7-4-5/h1-2,4H,3,6H2

InChIKey

DUDAKCCDHRNMDJ-UHFFFAOYSA-N

SMILES

C1SC=CC=1CN

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

2735

Hazard Note 

Corrosive

HazardClass 

IRRITANT

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

29349990

3-Thienylmethylamine Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

3-Thiophenemethylamineis an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

General procedure for the synthesis of 3-aminomethylthiophene from 3-cyanothiophene: Ruthenium(II) complex (1 M) and 2-butanol (5 mL) were added to a 25 mL flask under argon protection and stirred for 5 min at room temperature. Subsequently, KOtBu (0.05 mM) was added and stirring was continued for 5 minutes. Next, 3-cyanothiophene (0.5 mM) was added and the reaction mixture was heated on a hot plate at 120°C for 30 minutes. Upon completion of the reaction, the catalyst was removed by addition of petroleum ether followed by filtration. The filtrate was neutralized with 1 M HCl. The ether layer was purified by short path silica gel column chromatography. Hexadecane was added to the purified filtrate as an internal standard and the yield of the product 3-aminomethylthiophene was determined by gas chromatography (GC).

References

[1] Organic Process Research and Development, 2012, vol. 16, # 1, p. 109 - 116
[2] Chemistry - A European Journal, 2016, vol. 22, # 14, p. 4991 - 5002
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 47, p. 14653 - 14657
[4] Angew. Chem., 2016, vol. 128, # 47, p. 14873 - 14877,5
[5] Journal of Coordination Chemistry, 2015, vol. 68, # 2, p. 321 - 334

3-Thienylmethylamine(27757-86-4)Related Product Information

• SILIBININ-N-METHYLGLUCAMINE, 95％ （HPLC）
• Meglumine
• Cephalothin sodium
• trimethylamine oxide
• Thiophene
• Flunixin meglumine
• Tetrahydrothiophene
• Trimethylamine
• 3-Thiophenezoic acid
• 3-Thienylmethanol
• Methylamine
• 2-THIENYLMETHYLAMINE
• 3-Thienylmethylamine