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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID

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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Basic information

Product Name:
3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
Synonyms:
  • 3,3’,5,5’-tetraiodo-thyroaceticaci
  • 3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)-benzeneaceticaci
  • 3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneaceticacid
  • acide3,5,3’,5’-tetraiodothyroacetique
  • Levothyroxine – Impurity D
  • Liothyronine EP Impurity D
  • tetraiodothyroaceticacid
  • 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid
CAS:
67-30-1
MF:
C14H8I4O4
MW:
747.83
EINECS:
200-649-1
Product Categories:
  • Aromatic Phenylacetic Acids and Derivatives
  • Aromatics
  • Drug Analogues
  • Impurities
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
67-30-1.mol
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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Chemical Properties

Melting point:
219-220 °C (decomp)
Boiling point:
544.8±50.0 °C(Predicted)
Density 
2.727±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
acetone: soluble19.60 - 20.40mg/mL, clear, colorless (or faintly yellow to yellow)
form 
powder to crystal
pka
3.98±0.10(Predicted)
color 
White to Yellow to Green
InChI
InChI=1S/C14H8I4O4/c15-8-4-7(5-9(16)13(8)21)22-14-10(17)1-6(2-11(14)18)3-12(19)20/h1-2,4-5,21H,3H2,(H,19,20)
InChIKey
PPJYSSNKSXAVDB-UHFFFAOYSA-N
SMILES
C1(CC(O)=O)=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1
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Safety Information

Hazard Codes 
T+
Risk Statements 
28
Safety Statements 
45
RIDADR 
UN 2811 6.1/PG 1
WGK Germany 
3
RTECS 
CY1585800
HS Code 
2916.39.7900
HazardClass 
6.1

MSDS

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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Usage And Synthesis

Uses

Thyroid hormone analogue

Uses

3,3′,5,5′-Tetraiodothyroacetic acid has been used:

  • as a positive control to study the effects of ioxynil (IOX)
  • diethylstilbestrol (DES) exposure on zebrafish embryos
  • to study its effects on long-term potentiation (LTP) and long-term depression (LTD) in the dentate gyrus in urethane-anesthetized male rats
  • to determine its influence on the actions of thyroid-stimulating hormone
  • thyroid-stimulating immunoglobulins in orbital fibroblast

Definition

ChEBI: A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'.

Biochem/physiol Actions

Studies in rats have reported that Tetrac may regulate TSH secretion under in vivo conditions1.

in vivo

Tetrac (35 μg; p.o. for 40 days) inhibits tumor inoculation, growth and integrin expression in mice[4].

Animal Model:Wild-type male Balb/C mice aged 8 weeks are inoculated with 102B16F10 or B16LS9 cells[4]
Dosage:35 μg per day
Administration:P.o. (added to the drinking water) daily for 40 days
Result:Delayed the onset of ocular melanoma.
Reduced the S-100 and integrin staining level in the B16F10 mice model.

3,3',5,5'-TETRAIODOTHYRO-ACETIC ACIDSupplier

Shifang ShengYuan Technology Co., Ltd. Gold
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
Email
info@hanhongsci.com
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