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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID

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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Basic information

Product Name:
3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID
Synonyms:
  • 3,3’,5,5’-tetraiodo-thyroaceticaci
  • 3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)-benzeneaceticaci
  • 3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneaceticacid
  • acide3,5,3’,5’-tetraiodothyroacetique
  • Levothyroxine – Impurity D
  • Liothyronine EP Impurity D
  • tetraiodothyroaceticacid
  • 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid
CAS:
67-30-1
MF:
C14H8I4O4
MW:
747.83
EINECS:
200-649-1
Product Categories:
  • Aromatic Phenylacetic Acids and Derivatives
  • Aromatics
  • Drug Analogues
  • Impurities
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
67-30-1.mol
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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Chemical Properties

Melting point:
219-220 °C (decomp)
Boiling point:
544.8±50.0 °C(Predicted)
Density 
2.727±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
acetone: soluble19.60 - 20.40mg/mL, clear, colorless (or faintly yellow to yellow)
form 
powder to crystal
pka
3.98±0.10(Predicted)
color 
White to Yellow to Green
InChIKey
PPJYSSNKSXAVDB-UHFFFAOYSA-N
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Safety Information

Hazard Codes 
T+
Risk Statements 
28
Safety Statements 
45
RIDADR 
UN 2811 6.1/PG 1
WGK Germany 
3
RTECS 
CY1585800
HS Code 
2916.39.7900

MSDS

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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID Usage And Synthesis

Uses

Thyroid hormone analogue

Uses

3,3′,5,5′-Tetraiodothyroacetic acid has been used:

  • as a positive control to study the effects of ioxynil (IOX)
  • diethylstilbestrol (DES) exposure on zebrafish embryos
  • to study its effects on long-term potentiation (LTP) and long-term depression (LTD) in the dentate gyrus in urethane-anesthetized male rats
  • to determine its influence on the actions of thyroid-stimulating hormone
  • thyroid-stimulating immunoglobulins in orbital fibroblast

Definition

ChEBI: A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'.

Biochem/physiol Actions

Studies in rats have reported that Tetrac may regulate TSH secretion under in vivo conditions1.

3,3',5,5'-TETRAIODOTHYRO-ACETIC ACIDSupplier

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3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID(67-30-1)Related Product Information