2'-HYDROXY-4',5'-DIMETHOXYACETOPHENONE Chemical Properties

Melting point:

113-114°C

Boiling point:

332.3±37.0 °C(Predicted)

Density 

1.172±0.06 g/cm3(Predicted)

pka

10.29±0.23(Predicted)

form 

powder

color 

White to Light yellow to Light orange

CAS DataBase Reference

20628-06-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2914500090

MSDS

• Language:English Provider:SigmaAldrich

2'-HYDROXY-4',5'-DIMETHOXYACETOPHENONE Usage And Synthesis

Uses

1-(2-Hydroxy-4,5-dimethoxyphenyl)ethanone is a useful reagent in Vilsmeier-Haack reaction.

Preparation

Preparation by partial methylation of 2,5-dihydroxy-4-methoxyacetophenone, ? with methyl iodide in the presence of potassium carbonate in refluxing acetone (81%) ; ? with dimethyl sulfate in the presence of potassium carbonate in refluxing acetone (71%), in the presence of sodium methoxide in methanol (byproduct) or in the presence of sodium hydroxide in boiling aqueous ethanol (37%) ; ? with an excess of ethereal diazomethane in methanol (93%).

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