Basic information Safety Supplier Related

GYPENOSIDE-XVII

Basic information Safety Supplier Related

GYPENOSIDE-XVII Basic information

Product Name:
GYPENOSIDE-XVII
Synonyms:
  • GYPENOSIDE-XVII
  • GP-17
  • 3β-(β-D-Glucopyranosyloxy)-12β-hydroxy-5α-dammar-24-en-20-yl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside
  • Gypenoside ⅩⅦ
  • (3beta,12beta)-3-(beta-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-20-yl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
  • Gynosaponin S
  • Gypenoside XVII (Gynosaponin S)
  • β-D-Glucopyranoside, (3β,12β)-3-(β-D-glucopyranosyloxy)-12-hydroxydammar-24-en-20-yl 6-O-β-D-glucopyranosyl-
CAS:
80321-69-3
MF:
C48H82O18
MW:
947.15
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
80321-69-3.mol
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GYPENOSIDE-XVII Chemical Properties

Melting point:
>183°C (dec.)
Boiling point:
1013.5±65.0 °C(Predicted)
Density 
1.38
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)
form 
Solid
pka
12.90±0.70(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
InChIKey
ZRBFCAALKKNCJG-LBKPMPSYNA-N
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GYPENOSIDE-XVII Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Fiveleaf Gynostemma Herb.

Uses

Gypenoside XVII is a major saponin abundant in ginseng and Panax notoginseng which ameliorated amyloid-(Aβ)25-35-induced apoptosis in PC12 cells by regulating autophagy.

Definition

ChEBI: Gypenoside XVII is a ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 3 and 20 have been converted to the corresponding beta-D-glucopyranoside and beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite. It is a 12beta-hydroxy steroid, a beta-D-glucoside, a disaccharide derivative, a ginsenoside and a tetracyclic triterpenoid. It derives from a hydride of a dammarane.

in vivo

Body weights are measured as physical measures of hormone bioactivity. Mean body weights are significantly higher in every group compared to that of the control, but there is no significant difference in body weight between the different treatments during the 10-week feeding. The mouse plasma lipid levels are also measured at the end of 10 weeks of a high-fat diet. Circulating levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are significantly increased in the treated groups of ApoE-/- mice compared with those of the C57BL/6J control group; Gypenoside XVII (GP-17) and Probucol treatment substantially decreases both of these parameters relative to those of the ApoE-/- model group[1].

GYPENOSIDE-XVIISupplier

Shanghai Winherb Medical Technology Co., Ltd. Gold
Tel
021-38218169 13341702378
Email
winherb@126.com
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Email
cdhxsj@163.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Email
y.liu@mail.biobiopha.com
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Email
shyysw007@163.com
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GYPENOSIDE-XVII(80321-69-3)Related Product Information