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ISOLIQUIRITIN

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ISOLIQUIRITIN Basic information

Product Name:
ISOLIQUIRITIN
Synonyms:
  • ISOLIQUIRITIN
  • (E)-1-(2,4-Dihydroxyphenyl)-3-[4-(β-D-glucopyranosyloxy)phenyl]-2-propen-1-one
  • [(E)-2',4'-Dihydroxychalcone-4-yl]β-D-glucopyranoside
  • 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-[4-(.beta.-D-glucopyranosyloxy)phenyl]-, (2E)-
  • Aids004475
  • Aids-004475
  • neoisoliquritin
  • 2',4,4'-Trihydroxychalcone 4-(beta-D-glucopyranoside)
CAS:
5041-81-6
MF:
C21H22O9
MW:
418.39
EINECS:
1308068-626-2
Product Categories:
  • sy
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Miscellaneous Natural Products
Mol File:
5041-81-6.mol
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ISOLIQUIRITIN Chemical Properties

Melting point:
185-186℃
Boiling point:
743.5±60.0 °C(Predicted)
Density 
1.528
storage temp. 
4°C, protect from light
solubility 
Soluble in methan
form 
powder
pka
7.46±0.35(Predicted)
color 
Ochre
biological source
plant
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ISOLIQUIRITIN Usage And Synthesis

Uses

It is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Definition

ChEBI: A monosaccharide derivative that is trans-chalcone substituted by hydroxy groups at positions 2' and 4' and a beta-D-glucopyranosyloxy group at position 4 respectively.

Biological Activity

Isoliquiritin triggers apoptotic cell death by increasing the levels of p53 and p21 in A549 non-small cell lung cancer cells while also inhibiting the p53-dependent pathway and revealing interactions with Akt activities. Futher, Isoliquiritin has demonstrated neuroprotective activity against oxidative stress and has the capability to restrain the growth of microbial pathogens.

in vivo

Isoliquiritin (0.31-3.1 mg/kg, i.p., once a day for 5 days) inhibits granuloma angiogenesis in mice[1].
Isoliquiritin (10-40 mg/kg, oral gavage) shows antidepressant-like effects in FST and TST tests in mice[2].
Isoliquiritin ((10 mg/kg/bw/day, p.o.) shows anti-oxidative and anti-Inflammatory properties, and relieves cationic BSA-Induced membranous glomerulonephritis in experimental rat model[5].

Animal Model:Mice in Forced Swimming Test (FST) and the Tail Suspension Test (TST)[2]
Dosage:10, 20 and 40 mg/kg
Administration:oral gavage
Result:Reduced the immobility time in the FST and TST in mice.
Increased 5-HT and NE level and Reduced the ratio of 5-HIAA/5-HT in the hippocampus, hypothalamus and cortex.

target

HIV

ISOLIQUIRITINSupplier

Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Email
cdhxsj@163.com
Aktin Chemicals, Inc.
Tel
86-28-85159085
Email
info@aktinchem.com
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Email
sales@sungening.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
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