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Isocorynoxeine

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Isocorynoxeine Basic information

Product Name:
Isocorynoxeine
Synonyms:
  • Isocorynoxeine
  • (16E,20α)-16,17,18,19-Tetradehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
  • (alphaE,1'S,6'R,7'S,8'aS)-6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid methyl ester
  • Isocorynoxeine, BR
  • Isocorynoxeine (7-Isocorynoxeine)
  • Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'R,7'S,8'aS)-
  • Isocorynoxeine USP/EP/BP
  • methyl (E)-2-[(3S,6'R,7'S,8'aS)-6'-ethenyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
CAS:
51014-29-0
MF:
C22H26N2O4
MW:
382.46
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
51014-29-0.mol
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Isocorynoxeine Chemical Properties

Boiling point:
562.7±50.0 °C(Predicted)
Density 
1.25
solubility 
DMSO : 50 mg/mL (130.74 mM; Need ultrasonic)
form 
Powder
pka
13.54±0.60(Predicted)
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Isocorynoxeine Usage And Synthesis

Description

The leaves of Mitragyna rotundlfolia grown in Burma have recently been found to contain this alkaloid. This is the first reported occurrence of the base in nature. The structure has been established from spectroscopic investigations.

Uses

7-Isocorynoxeine is a bioactive oxindole alkaloid in the Uncaria species. Displays wide array of beneficial cardiovascular and cardiocerebral vascular system effects.

target

5-HT2A receptor | NO

References

Houghton, Shellard, Planta Med., 26, 104 (1974)

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