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LICOCHALCONE-A

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LICOCHALCONE-A Basic information

Product Name:
LICOCHALCONE-A
Synonyms:
  • LICOCHALCONE-A
  • (E)-3-[5-(1,1-DIMETHYL-2-PROPENYL)-4-HYDROXY-2-METHOXYPHENYL]-1-(4-HYDROXYPHENYL)-2-PROPEN-1-ONE
  • 4′,4-Dihydroxy-3-α,α-dimethylallyl-6-methoxychalcone
  • 2-Propen-1-one, 3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (2E)-
  • (2E)-3-[4-Hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
  • 7-Dimethoxycoumarin
  • Licochalcone A, >=98%
  • Soluble LICOCHALCONE A, Liposomal LICOCHALCONE A, LICOCHALCONE A NanoEmulsion, NanoActive LICOCHALCONE A
CAS:
58749-22-7
MF:
C21H22O4
MW:
338.4
EINECS:
635-678-2
Product Categories:
  • The group of Liquorice
  • sy
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
58749-22-7.mol
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LICOCHALCONE-A Chemical Properties

Melting point:
100°
Boiling point:
532.6±50.0 °C(Predicted)
Density 
1.171±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMF:25.0(Max Conc. mg/mL);73.88(Max Conc. mM)
DMSO:37.67(Max Conc. mg/mL);111.31(Max Conc. mM)
Ethanol:43.5(Max Conc. mg/mL);128.54(Max Conc. mM)
pka
7.82±0.15(Predicted)
form 
Yellow solid
color 
Yellow-orange
BRN 
4534154
InChIKey
KAZSKMJFUPEHHW-DHZHZOJOSA-N
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36/37
WGK Germany 
3
RTECS 
UB8755000
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LICOCHALCONE-A Usage And Synthesis

Uses

Licochalcone A is an estrogenic flavonoid that induces apoptosis in multiple types of cancer cells. Licochalcone A applied to bone marrow mesenchymal stem cells (BMSC)-aggregate has strong osteogenetic differentiation thus providing a promising strategy in treating osteoporotic weight-bearing bone fractures with defects.

Definition

ChEBI: Licochalcone A is a member of chalcones.

General Description

An estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.

Biochem/physiol Actions

Inhibits vegetative growth of spore-forming bacteria, B. subtilis and other food-contaminating microorganisms.

LICOCHALCONE-ASupplier

Chengdu Nakeli Biotechnology Co., Ltd. Gold
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Nanjing Peiwill Biotechnology Co.,Ltd. Gold
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025-57027729 15850702895
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Nanjing puyi biotechnology co., LTD Gold
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Nanjing Yuanzhi Biotechnology Co. Ltd. Gold
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15805159960
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Sichuan Wei Keqi Biological Technology Co., Ltd. Gold
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028-81700200 18116577057
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