5,6-Diamino-1,3-dimethyluracil hydrate Chemical Properties

Melting point:

210-214 °C (dec.)(lit.)

Boiling point:

243.6±50.0℃ (760 Torr)

Density 

1.350±0.06 g/cm3 (20 ºC 760 Torr)

Flash point:

101.1±30.1℃

solubility 

DMSO, Methanol

pka

4.42±0.70(Predicted)

form 

Solid

color 

Pale Brown

BRN 

157451

EPA Substance Registry System

2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-1,3-dimethyl- (5440-00-6)

Safety Information

WGK Germany 

3

F 

10-34

5,6-Diamino-1,3-dimethyluracil hydrate Usage And Synthesis

Chemical Properties

Pale Brown Solid

Uses

5,6-Diamino-1,3-dimethyl Uracil (cas# 5440-00-6) is a compound useful in organic synthesis.

Uses

Reactant involved in the synthesis of biologically active molecules including:

• 1H-Imidazol-1-yl substituted 8-phenylxanthines for use as adenosine receptor ligands
• Pyrimidinyl purinediones via cyclocondensation
• Theophylline derivatives as adenosine receptor antagonists
• Pteridine analogs for use as monoamine oxidase B and nitric oxide synthase inhibitors
• Fused tricyclic xanthines
• Cadmium uraciliminoethylpyridine complexes for use as antiproliferatives against C6 glioma cells

Uses

5,6-Diamino-1,3-dimethyluracil hydrate can be used as reactant involved in the synthesis of biologically active molecules including: 1H-Imidazol-1-yl substituted 8-phenylxanthines for use as adenosine receptor ligands ; Pyrimidinyl purinediones via cyclocondensation ; Theophylline derivatives as adenosine receptor antagonists ; Pteridine analogs for use as monoamine oxidase B and nitric oxide synthase inhibitors ; Fused tricyclic xanthines and Cadmium uraciliminoethylpyridine complexes for use as antiproliferatives against C6 glioma cells6.

Purification Methods

It recrystallises from EtOH. The hydrochloride has m 310o (from MeOH), and the perchlorate has m 246-248o. [UV: Bredereck et al. Chem Ber 92 583 1959, Taylor et al. J Am Chem Soc 77 2243 1955, Beilstein 25 III/IV 4133.]

5,6-Diamino-1,3-dimethyluracil hydrate(5440-00-6)Related Product Information

• 6-(HYDROXYMETHYL)URACIL
• 2,4-Dihydroxypyrimidine-5-carboxylic acid
• 2-(2-chloropyriMidin-5-yl)propan-2-ol
• dihydro-6-imino-1,3-dimethyl-3H-pyrimidine-2,4,5-trione 5-oxime
• (E)-5-(2-BROMOVINYL)URACIL
• 5-CARBOXYCYTOSINE
• OROTIC ACID MONOHYDRATE
• dihydro-6-imino-1,3-dimethyluracil
• 6-FORMYL-URACIL MONOHYDRATE
• Pyrimidine, 4-(chloromethyl)-2,6-dimethoxy-
• Tetrahydrofuryluracil
• Pyrimidine, 5-chloro-4-(chloromethyl)-2,6-dimethoxy-
• 1,3-Dimethyluric acid
• 6-AMINO-1,3-DIMETHYL-5-NITROSOURACIL
• 1,3,7-TRIMETHYLURIC ACID
• TETRAMETHYLURIC ACID
• 5,6-Diamino-1,3-dimethyluracil hydrate
• 1,3-Dimethylurea