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2-Thiophenethiol

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2-Thiophenethiol Basic information

Product Name:
2-Thiophenethiol
Synonyms:
  • FEMA 3062
  • 2-MERCAPTOTHIOPHENE
  • Thienylmercaptan
  • 2-Mercaptothiophene~2-Thienyl mercaptan
  • 2-MERCAPTOTHIOPHENE FEMA NO.--------
  • Thiophene-2-thiol,97%
  • Thiophene-2-thiol,96%
  • 2-Thiophenethiol(6CI,7CI,8CI,9CI)
CAS:
7774-74-5
MF:
C4H4S2
MW:
116.2
EINECS:
231-881-1
Product Categories:
  • Heterocycle-oher series
  • THIOL
  • Thiophene&Benzothiophene
  • thiol Flavor
Mol File:
7774-74-5.mol
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2-Thiophenethiol Chemical Properties

Boiling point:
129 °C(lit.)
Density 
1.252 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.62(lit.)
FEMA 
3062 | 2-THIENYL MERCAPTAN
Flash point:
150 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
soluble in Chloroform, DMSO
form 
clear liquid
pka
6.38±0.43(Predicted)
color 
Light yellow to Brown
Odor
at 0.10 % in dipropylene glycol. burnt caramel roasted coffee
Odor Type
caramellic
Sensitive 
Air Sensitive
JECFA Number
1052
BRN 
104650
InChIKey
SWEDAZLCYJDAGW-UHFFFAOYSA-N
LogP
2.20
CAS DataBase Reference
7774-74-5(CAS DataBase Reference)
NIST Chemistry Reference
2-Thiophenethiol(7774-74-5)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-36/38-21/22-20/22
Safety Statements 
26-36-36/37/39
RIDADR 
UN3334
WGK Germany 
3
10-13-23
Hazard Note 
Irritant
HazardClass 
9
PackingGroup 
III
HS Code 
29349990

MSDS

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2-Thiophenethiol Usage And Synthesis

Chemical Properties

Clear yellowish to orange liquid

Chemical Properties

2-Thienyl mercaptan has a very unpleasant, burnt caramellic and sulfuraceous odor with a similar flavor.

Uses

2-Thiophenethiol is used in biological studies to evaluate the changes in key odorants of hazelnut induced by roasting.

Definition

ChEBI: Thiophene-2-thiol is a heteroarene.

Preparation

By heating sodium sulfosuccinate with phosphorous trichloride; also by reduction of thiophene-2-sulfonyl chloride.

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 6316, 1953 DOI: 10.1021/ja01120a518

Synthesis

A three-necked flask fitted with a mechanical stirrer and a 600-ml dropping funnel filled with dry nitrogen is charged with 500 ml of tetrahydrofuran and 56 g (53 ml, 0.67 mole) of thiophene. This mixture is stirred under nitrogen and cooled to ?40° with an acetone–dried ice bath while 490 ml (0.662 mole) of 1.35 M n-butyllithium in pentane is added over 5 minutes via the dropping funnel. The mixture's temperature is held between ?30° and ?20° for 1 hour, then lowered to ?70° by adding dry ice to the bath. Powdered sulfur crystals (20.4 g, 0.638 g) are added to the stirred mixture in one aliquot. After 30 minutes, the temperature is allowed to rise to ?10°, and then the yellow solution is carefully poured into 1 l of rapidly stirred ice water. These aqueous extracts are combined with the aqueous layer, and the whole is chilled and carefully acidified with 4 N sulfuric acid. This aqueous phase is immediately extracted with three 200-ml portions of diethyl ether. The combined ether extracts are washed twice with 100 ml portions of water to remove acid and remaining tetrahydrofuran and dried over anhydrous sodium sulfate. After the removal of ether, the residual golden-brown oil is purified by distillation at reduced pressure. The portion boiling at 53–56° (5 mm) is collected, yielding 49.5–53.5 g (65–70%) of 2-thiophenethiol as a yellow oil.

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