5-Chlorothiophene-2-sulfonyl chloride Chemical Properties

Melting point:

25-28°C

Boiling point:

112-117 °C (lit.)

Density 

1.623 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.586(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

form 

solid

Specific Gravity

1.623

color 

Colorless to Yellow to Orange

Water Solubility 

Not miscible in water.

Sensitive 

Moisture Sensitive

BRN 

130710

InChIKey

SORSTNOXGOXWAO-UHFFFAOYSA-N

CAS DataBase Reference

2766-74-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34-29-14

Safety Statements 

26-27-36/37/39-45-28A-25

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

II

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Chlorothiophene-2-sulfonyl chloride Usage And Synthesis

Chemical Properties

5-Chlorothiophene-2-sulfonyl chloride is white to yellow crystalline low melting solid

Uses

5-Chloro-2-thiophenesulfonyl Chloride is a sulfonylthiophene derivative used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.

Uses

5-Chlorothiophene-2-sulfonyl chloride is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs. It is used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.

Synthesis Reference(s)

Tetrahedron, 21, p. 1333, 1965 DOI: 10.1016/S0040-4020(01)98293-6

General Description

5-Chlorothiophene-2-sulfonyl chloride can be prepared from 2-chlorothiophene by reacting with chlorosulfonic acid in the presence of phosphorus pentachloride.

5-Chlorothiophene-2-sulfonyl chloride(2766-74-7)Related Product Information

• Ethanesulfonyl chloride
• Chloromethanesulfonyl chloride
• Benzenesulfonyl chloride
• Mepiquat chloride
• Calcium chloride
• Ammonium chloride
• Sulfuryl chloride
• Benzyl chloride
• Choline chloride
• Tosyl chloride
• 4-Nitrobenzenesulfonyl chloride
• Polyvinyl chloride
• Sodium chloride
• Methylene Chloride
• 3-BROMO-5-CHLOROTHIOPHENE-2-SULFONYL CHLORIDE,3-Bromo-5-chlorothiophene-2-sulfonyl chloride, 95+%
• 5-CHLORO-4-NITROTHIOPHENE-2-SULFONYL CHLORIDE
• 4-Bromo-5-chlorothiophene-2-sulfonyl chloride, 95+%,4-BROMO-5-CHLOROTHIOPHENE-2-SULFONYL CHLORIDE,3-BROMO-2-CHLOROTHIOPHENE-5-SULFONYL CHLORIDE
• 2,3-Dichlorothiophene-5-sulphonyl chloride